Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase.
Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase.
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DOI：
10.1007/s10096-005-1299-5
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发表时间：
2005-03
期刊：
影响因子：
--
通讯作者：
Wang FS
中科院分区：
文献类型：
--
作者：
Xu D;Zhang Z;Jin L;Chu F;Mao Y;Wang H;Liu M;Wang M;Zhang L;Gao GF;Wang FS
为了进一步了解新出现的严重急性呼吸综合征相关冠状病毒（SARS-CoV），对54例临床诊断为SARS患者的486份不同标本进行了病毒RNA检测，并对73例患者的314份血浆标本进行了SARS-CoV特异性IgM和IgG抗体检测。在54名受试者中，有28名检测到病毒RNA。累积数据显示，73名SARS患者中有67人在发病第5周出现血清转化。相比之下，在研究中招募的278名健康受试者中，仅发现1名IgG抗体阳性。在两例危重病例中，连续三周同时观察到血浆中病毒RNA和特异性抗体的共存。特别是在三名康复期患者中，在粪便或尿液标本中检测到可培养的SARS-CoV超过4周（29-36天）。这些发现表明SARS-CoV可能在恢复期患者的排泄物中保持活力。
In order to further the present knowledge of the emerging severe acute respiratory syndrome-associated coronavirus (SARS-CoV), 486 different specimens from 54 patients with a clinical diagnosis of SARS were investigated for the presence of viral RNA, and 314 plasma specimens of 73 patients were examined for IgM and IgG antibodies specific against SARS-CoV using an indirect ELISA. Viral RNA was detectable in 28 of the 54 patients tested. Cumulative data showed that 67 of the 73 SARS patients demonstrated seroconversion by week 5 of illness. In contrast, only 1 of 278 healthy subjects enrolled in the study was found to be positive for the IgG antibody. Coexistence of viral RNA in plasma and specific antibodies was simultaneously observed over three consecutive weeks in two critical cases. In three convalescent patients in particular, cultivable SARS-CoV was detected in stool or urine specimens for longer than 4 weeks (29–36 days). These findings suggest that SARS-CoV may remain viable in the excretions of convalescent patients.
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DOI：
10.1016/s0140-6736(03)13077-2
发表时间：
2003-04-19
期刊：
Lancet (London, England)
影响因子：
--
作者：
Peiris JS;Lai ST;Poon LL;Guan Y;Yam LY;Lim W;Nicholls J;Yee WK;Yan WW;Cheung MT;Cheng VC;Chan KH;Tsang DN;Yung RW;Ng TK;Yuen KY;SARS study group
通讯作者：
SARS study group
影响因子：
11.8
作者：
Leung GM;Chung PH;Tsang T;Lim W;Chan SK;Chau P;Donnelly CA;Ghani AC;Fraser C;Riley S;Ferguson NM;Anderson RM;Law YL;Mok T;Ng T;Fu A;Leung PY;Peiris JS;Lam TH;Hedley AJ
通讯作者：
Hedley AJ
DOI：
10.1016/j.jcv.2003.08.004
发表时间：
2003-12
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Poon LL;Chan KH;Wong OK;Yam WC;Yuen KY;Guan Y;Lo YM;Peiris JS
通讯作者：
Peiris JS
影响因子：
9.3
作者：
Poon, LLM;Chan, KH;Peiris, JSM
通讯作者：
Peiris, JSM
DOI：
10.1016/j.jcv.2003.09.011
发表时间：
2004-01
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Berger A;Drosten Ch;Doerr HW;Stürmer M;Preiser W
通讯作者：
Preiser W