INFLUENCE OF FAT-RICH VERSUS CARBOHYDRATE-RICH DIETS ON BILE-ACID KINETICS, BILIARY LIPIDS, AND NET STEROID BALANCE IN HYPERLIPIDEMIC SUBJECTS
INFLUENCE OF FAT-RICH VERSUS CARBOHYDRATE-RICH DIETS ON BILE-ACID KINETICS, BILIARY LIPIDS, AND NET STEROID BALANCE IN HYPERLIPIDEMIC SUBJECTS
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DOI：
10.1016/0026-0495(80)90163-8
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发表时间：
1980-01-01
影响因子：
9.8
通讯作者：
HELLSTROM, K
中科院分区：
文献类型：
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作者：
ANDERSEN, E;HELLSTROM, K
高脂蛋白血症IIa型患者(14例)。=3)、IIb(No.=4)或IV(No.=7)在60%能量以脂肪或碳水化合物形式提供的日粮中维持。从高脂肪饮食转变为高碳水化合物饮食导致了血浆甘油三酯水平的升高。虽然不是在所有情况下都是一致的，但改变饮食导致胆酸和鹅去氧胆酸在十二指肠胆汁中的形成增加，脱氧胆酸的贡献更高。由于粪便中中性类固醇排泄量的递减，平均类固醇平衡保持不变。在所有患者中，除了4名患者外，这种饮食改变与十二指肠胆汁中摩尔胆固醇浓度的降低有关，这些胆汁在吸收后状态下获得。
Patients (14) with hyperlipoproteinemia type IIa (no. = 3), IIb (no. = 4) or IV (no. = 7) were maintained on diets in which 60% of the energy was supplied as fat or carbohydrates. The switch from the fat-rich to the carbohydrate-rich diet resulted in elevation of the plasma triglyceride levels. Although not consistent in all instances, the change of diet resulted in an enhanced formation of cholic acid and chenodeoxycholic acid and a higher contribution of deoxycholic acid in duodenal bile. Due to a reciprocal decrease in the excretion of neutral steroids in feces, the mean steroid balance remained unchanged. In all but 4 patients, this switch of diets was associated with a decreased molar cholesterol concentration in duodenal bile obtained in the postabsorptive state.