Characterization of fibrin/fibrinogen degradation products reagents and their utility in critical care patients with enhanced fibrinolysis
Characterization of fibrin/fibrinogen degradation products reagents and their utility in critical care patients with enhanced fibrinolysis
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纤维蛋白/纤维蛋白原降解产物试剂的表征及其在增强纤维蛋白溶解的重症监护患者中的效用
DOI：
10.1111/ijlh.13428
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发表时间：
2021
影响因子：
3
通讯作者：
Hayakawa Mineji
中科院分区：
文献类型：
--
作者：
Kumano Osamu;Ieko Masahiro;Komiyama Yutaka;Naito Sumiyoshi;Yoshida Mika;Takahashi Nobuhiko;Ohmura Kazumasa;Hayakawa Mineji
纤维蛋白原/纤维蛋白原降解产物（FDP）的测定反映了凝血和纤溶状态，有助于弥散性血管内凝血（DIC）的诊断和分型。FDP测量一直在诊断DIC中发挥着关键作用，这种现象最近因其在2019冠状病毒病（COVID-19）患者中的发生而重新受到关注。尽管FDP的评价对于重症监护的管理至关重要，但FDP试剂之间的变异性尚不清楚。在这项研究中，我们的目的是比较LIASAUTO P-FDP与三种FDP试剂，并探讨其特点。根据LIASAUTO P-FDP与其他三种试剂之间的每种相关性计算的差异百分比，将样本数据分为阴性、无和阳性差异三组。结果D-二聚体、纤溶酶-α 2纤溶酶抑制剂复合物（PIC）、纤维蛋白单体复合物（FMC）、纤维蛋白原（Fbg）、纤溶酶-α 2纤溶酶抑制剂（α 2 PI）阳性差异组均高于阴性差异组。结论LIASAUTO P-FDP对多种纤维蛋白/纤维蛋白原降解产物具有较强的反应性，不同类型、不同分期的DIC患者纤溶状态不同，因此LIASAUTO P-FDP对DIC的诊断有一定的参考价值。
IntroductionFibrin/fibrinogen degradation products (FDP) values reflect coagulation and fibrinolysis status, and FDP levels are helpful for diagnosis and classification of disseminated intravascular coagulation (DIC). FDP measurement has always played a key role in diagnosing DIC, a phenomenon that has recently gained renewed attention because of its occurrence in coronavirus disease 2019 (COVID‐19) patients. Although the evaluation of FDP is crucial for the management of critical care, the variability among FDP reagents is unclear. In this study, we aimed to compare LIASAUTO P‐FDP with three FDP reagents and investigate their characteristics.MethodsIn total, 172 plasmas samples were used in the correlation. The sample data were divided into three groups including negative, no and positive discrepancy based on the discrepancy percentages calculated from each correlation between LIASAUTO P‐FDP and other three reagents. D‐dimer, plasmin‐α2plasmin inhibitor complex (PIC), fibrin monomer complex (FMC), fibrinogen (Fbg) and Plasmin‐α2Plasmin Inhibitor (α2PI) were measured and included in data analysis.ResultsThe positive discrepancy groups showed higher D‐dimer, PIC and FMC values than the negative discrepancy groups. The data indicated that LIASAUTO P‐FDP had higher reactivity to D‐dimer than other reagents and the values were elevated in the fibrinolysis‐enhanced samples with various FDP fragments.ConclusionLIASAUTO P‐FDP displayed the reactivity towards various fibrin/fibrinogen degradation products, and it might be useful for DIC diagnosis because the fibrinolytic status differed in the DIC types and stages.