The development of thought problems: a longitudinal family risk study of offspring of bipolar, unipolar, and well parents.
The development of thought problems: a longitudinal family risk study of offspring of bipolar, unipolar, and well parents.
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思想问题的发展：双相、单相和健康父母后代的纵向家庭风险研究。
DOI：
10.1017/s0954579413000382
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发表时间：
2013
影响因子：
3.3
通讯作者：
Martinez,PedroE
中科院分区：
文献类型：
--
作者：
Klimes-Dougan,Bonnie;Desjardins,ChristopherDavid;James,MatthewG;Narayan,AngelaJ;Long,JeffreyD;Cullen,KathrynR;Gold,PhilipW;Martinez,PedroE
越来越多的证据表明，父母患有双相情感障碍（BD）的许多后代在儿童期和青春期会发展出中度至重度的精神病理学，包括思维问题。本研究的目的是在家庭风险研究的背景下，评估思想问题的发展进程。在父母诊断为BD（O-BD）、单相抑郁（O-UNI）或无显著精神或医学问题（O-WELL）的后代（来自98个家庭的N = 192）中进行了思维问题的重复评估，时间跨度约为15年。生存分析表明，O-BD组随着时间的推移发展思想问题的估计概率最大，其次是O-UNI，然后是O-WELL和O-BD表现出比O-WELL更高的持久性水平。父母报告的儿童和青少年时期的思维问题预示着成年后的一系列问题。现实测试中的干扰和其他非典型行为可能会破坏重要发展时期的进展，并与不良结果有关。这些发现可能与预防双相父母后代问题的发生或进展有关。在发展过程中的思维问题的研究是一个重要的领域，继续研究儿童的风险发展的情感障碍。
There is growing evidence that many offspring of parents with bipolar disorder (BD) will develop moderate to severe forms of psychopathology during childhood and adolescence, including thought problems. The purpose of this study was to evaluate the developmental progression of thought problems within the context of a family risk study. Repeated assessments of thought problems, spanning approximately 15 years, were conducted in offspring (N = 192 from 98 families) of parents diagnosed with BD (O-BD), unipolar depression (O-UNI), or no significant psychiatric or medical problems (O-WELL). Survival analysis showed that the O-BD group had the greatest estimated probability of developing thought problems over time, followed by O-UNI, and then O-WELL and O-BD exhibiting higher levels of persistence than O-WELL. Parent-reported thought problems in childhood and adolescence predicted a range of problems in young adulthood. Disturbances in reality testing and other atypical behaviors are likely to disrupt progression through important developmental periods and to associate with poor outcomes. These findings are likely relevant to preventing the occurrence or progression of problems in offspring of bipolar parents. The study of thought problems across development represents an important area of continued research in children at risk for development of affective disorders.