Measurement of Osteocalcin
Measurement of Osteocalcin
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DOI：
10.1177/000456320003700402
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发表时间：
2000-07
影响因子：
2.2
通讯作者：
Allison Lee;S. Hodges;R. Eastell
中科院分区：
文献类型：
--
作者：
Allison Lee;S. Hodges;R. Eastell
骨转换可以通过测量由成骨细胞（其形成骨）或破骨细胞（其再吸收骨）产生的酶或基质蛋白来评估。“引入可靠、特异的骨代谢生化标志物检测将有助于包括骨质疏松症在内的代谢性骨病的临床管理。骨钙素，也称为骨Gla蛋白，是骨形成的标志物。它是由成骨细胞产生的维生素K和维生素O依赖性蛋白，是骨中最丰富和研究最广泛的非胶原蛋白。4图一。骨钙素二级结构示意图。G/a残基存在于位置17处。21和24之间存在二硫桥，23和29之间存在二硫桥。
Bone turnover may be assessed by the measurement of enzymes or matrix proteins produced by osteoblasts (which form bone) or osteoclasts (which resorb bone).' The introduction of reliable, specific tests for the biochemical markers of bone metabolism would aid in the clinical management of metabolic bone diseases, including osteoporosis. Osteocalcin, also known as bone Gla protein, is a marker of bone formation. It is a vitamin Kand vitamin O-dependent protein produced by osteoblasts and is the most abundant and most widely studied of the non-collagenous proteins in bone.? 4 FIGURE I. Diagram of the secondary structure of osteocalcin. G/a residues are present at positions 17. 21 and 24 and a disulphide bridge is present hetween residues 23 and 29.