Overexpression of miR-210 is Associated with Poor Prognosis of Acute Myeloid Leukemia.
Overexpression of miR-210 is Associated with Poor Prognosis of Acute Myeloid Leukemia.
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DOI：
10.12659/msm.894812
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发表时间：
2015-11-09
期刊：
影响因子：
--
通讯作者：
Zhou X
中科院分区：
文献类型：
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作者：
Tang X;Chen L;Yan X;Li Y;Xiong Y;Zhou X
MicroRNA 在调节 AML 的发生和进展中发挥着重要作用。 MiR-210与癌症发生密切相关；然而，miR-210 表达水平是否与 AML 的临床相关性尚不清楚。因此，本研究的目的是探讨 miR-210 表达与 AML 预后之间的潜在关系。采用实时定量PCR检测AML患者和健康对照者的骨髓和血清中miR-210的表达水平。然后进一步研究miR-210表达与多种重要临床参数（如总生存期、无复发生存期和预后价值）之间的相关性。 AML患者骨髓和血清中miR-210的表达水平显着高于健康对照（p<0.001）。此外，miR-210 表达与各种 AML 临床病理参数相关，包括 FAB 分类和细胞遗传学。当患者达到完全缓解时，血清miR-210表达水平显着降低（p=0.02）。高miR-210表达组的无复发生存率较差(p=0.015)，总生存率较差(p=0.008)。在多变量分析模型中，miR-210被确定为独立的预后标志物。 MiR-210 上调与 AML 预后不良相关，它可能可作为预测 AML 患者临床结果的标志物。
MicroRNAs play important roles in regulation of the initiation and progression of AML. MiR-210 is closely related with cancer development; however, whether miR-210 expression level correlates with clinical correlation in AML is unknown. Thus, the aim of this study was to investigate the potential relationship between miR-210 expression and AML prognosis. Real-time quantitative PCR was carried out to examine the expression level of miR-210 in bone marrow and serum obtained from AML patients and healthy controls. Then the correlation between miR-210 expression and a variety of important clinical parameters (such as overall survival, relapse-free survival, and prognostic value) were further studied. The expression level of miR-210 was significantly higher in the bone marrow and serum of AML patients than that of healthy controls (p<0.001). Moreover, miR-210 expression was associated with various AML clinicopathological parameters, including FAB classification and cytogenetics. The serum miR-210 expression level was reduced significantly when the patients achieved complete remission (p=0.02). The high miR-210 expression group had both poorer relapse-free survival (p=0.015) and worse overall survival (p=0.008). In the multivariate analysis model, miR-210 was identified as an independent prognostic marker. MiR-210 up-regulation was associated with poor prognosis in AML and it might be useful as a marker for predicting the clinical outcome of AML patients.