Chronic malaria and hyper-reactive malarial splenomegaly: a retrospective study on the largest series observed in a non-endemic country
Chronic malaria and hyper-reactive malarial splenomegaly: a retrospective study on the largest series observed in a non-endemic country
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DOI：
10.1186/s12936-016-1274-x
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发表时间：
2016-04-21
期刊：
影响因子：
3
通讯作者：
Buonfrate, Dora
中科院分区：
文献类型：
--
作者：
Bisoffi, Zeno;Leoni, Stefania;Buonfrate, Dora
背景：慢性疟疾通常被定义为半免疫受试者的长期疟疾感染，通常没有发烧或其他急性症状。未经治疗的感染可能会发展为高反应性疟疾脾肿大（HMS），这是一种危及生命的并发症。本文描述了在流行国家之外观察到的最大的 HMS 系列，以及单次抗疟疾治疗后的临床结果。与大多数作者相反，无论可能进一步接触，仍然报告传统的长期治疗，本系列中的患者如果没有再次接触疟疾感染，则不会接受任何进一步的预防。方法：一项回顾性纵向研究描述了在维罗纳内格拉尔热带疾病中心诊断的所有 HMS 患者，历时 25 年。 HMS 的定义是脾脏纵向直径 >= 16 cm、IgM >= 2.5 g/L、抗疟疾抗体滴度 >= 160，排除脾肿大的其他原因。短期（
Background: Chronic malaria is usually defined as a long-term malarial infection in semi-immune subjects, usually without fever or other acute symptoms. The untreated infection may evolve to hyper-reactive malarial splenomegaly (HMS), a life-threatening complication. This paper describes the largest series of HMS ever observed outside endemic countries, and the clinical outcome after a single anti-malarial treatment. Contrarily to most authors, still reporting the traditional, long-term treatment, regardless possible further exposure, the patients in this series did not receive any further prophylaxis if they were not re-exposed to malaria infection.Methods: A retrospective, longitudinal study, describing all patients with HMS diagnosed at the Centre for Tropical Diseases of Negrar, Verona, took place over a 25-year period. HMS was defined by a longitudinal spleen diameter >= 16 cm, IgM >= 2.5 g/L, anti-malarial antibody titre >= 160, exclusion of other causes of splenomegaly. The short-term (