Contrasting views on the role of AMPK in autophagy.
Contrasting views on the role of AMPK in autophagy.
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DOI：
10.1002/bies.202300211
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发表时间：
2024-01
期刊：
影响因子：
4
通讯作者：
Do-Hyung Kim
中科院分区：
文献类型：
--
作者：
Do-Hyung Kim
低能量状态的有效管理对于细胞维持基本功能和新陈代谢并避免细胞死亡至关重要。虽然自噬长期以来一直被认为是确保能量耗尽期间生存的关键机制，但最近的研究提出了相互矛盾的证据，挑战了长期以来的概念。最近的进展表明，当细胞能量有限时，细胞会优先保留必需的细胞成分，同时抑制自噬诱导。本文探讨了能量应激期间自噬调节的概念性论述，浏览了建立当前范式的研究以及挑战其有效性同时提出替代模型的最新研究。这一探索强调了替代模型的深远影响，该模型代表了与既定范式的概念背离，为细胞如何应对能量压力提供了新的视角。
Efficient management of low energy states is vital for cells to maintain basic functions and metabolism and avoid cell death. While autophagy has long been considered a critical mechanism for ensuring survival during energy depletion, recent research has presented conflicting evidence, challenging the long‐standing concept. This recent development suggests that cells prioritize preserving essential cellular components while restraining autophagy induction when cellular energy is limited. This essay explores the conceptual discourse on autophagy regulation during energy stress, navigating through the studies that established the current paradigm and the recent research that has challenged its validity while proposing an alternative model. This exploration highlights the far‐reaching implications of the alternative model, which represents a conceptual departure from the established paradigm, offering new perspectives on how cells respond to energy stress.