A catalysis study of mesoporous MCM-41 supported Schiff base and CuSO4·5H2O in a highly regioselective synthesis of 4-thiazolidinone derivatives from cyclocondensation of mercaptoacetic acid
A catalysis study of mesoporous MCM-41 supported Schiff base and CuSO4·5H2O in a highly regioselective synthesis of 4-thiazolidinone derivatives from cyclocondensation of mercaptoacetic acid
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DOI：
10.1016/j.cclet.2015.10.029
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发表时间：
2016-03
影响因子：
9.1
通讯作者：
Haiduo Pang;Y. Hui;Kui Fan;Xue-Jian Xing;Yang Wu;Jing-Hui Yang;W. Shi;Zhengfeng Xie
中科院分区：
文献类型：
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作者：
Haiduo Pang;Y. Hui;Kui Fan;Xue-Jian Xing;Yang Wu;Jing-Hui Yang;W. Shi;Zhengfeng Xie
介孔分子筛MCM-41负载Schiff碱和CuSO 4·5 H2O催化巯基乙酸与亚胺（或醛、胺）的环化缩合反应，合成了具有重要药用价值的噻唑烷酮衍生物。两组分或三组分的催化反应以高收率（高达98%和99%）得到所需产物。此外，该催化剂在可循环性方面表现良好，在循环六次后，产物的产率为85%和83%。
Mesoporous MCM-41 supported Schiff base and CuSO4·5H2O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines (or aldehydes and amines) to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving two-components or three-components afforded the desired product in high yields (up to 98% and 99%). Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.