Predisposition to atherosclerosis in the head, heart, and legs. The Framingham study.
Predisposition to atherosclerosis in the head, heart, and legs. The Framingham study.
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头部、心脏和腿部容易发生动脉粥样硬化。
DOI：
10.1001/jama.1972.03200200011003
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
W. Kannel
中科院分区：
文献类型：
--
作者：
T. Gordon;W. Kannel
一项对5,209名美国成年人进行的为期16年的随访研究结果表明，血压、血清胆固醇、吸烟、左心室肥大的心电图证据和葡萄糖耐受不良是所有三种主要动脉粥样硬化事件-动脉粥样硬化性脑梗死（ABI）、冠心病（CHD）和间歇性跛行（IC）的共同前兆。诱发ABI的主要因素是高血压。没有明显的优势冠心病。葡萄糖耐受不良与这种疾病的相关性很弱，而吸烟与心绞痛的相关性很弱（如果有的话）。这五个因素在IC中起着重要的作用。一般来说，男女之间的关系似乎一样牢固。当所有五个变量联合考虑时，它们与ABI和IC的关系比与CHD的关系更密切，并且在45至74岁之间的每个年龄组中具有同样强的关系。
Findings from a 16-year follow-up study of 5,209 Framingham adults indicate that blood pressure, serum cholesterol, cigarette smoking, electrocardiographic evidence of left ventricular hypertrophy, and glucose intolerance are precursors common to all three major atherosclerotic events—atherosclerotic brain infarction (ABI), coronary heart disease (CHD), and intermittent claudication (IC). The dominant factor predisposing to ABI is high blood pressure. None is clearly dominant for CHD. Glucose intolerance is only weakly related to this disease while cigarette smoking is related weakly (if at all) to angina pectoris. All five factors play an important role in IC. In general, relationships appear to be as strong for women as men. When all five variables are considered jointly, they have a closer relationship with ABI and IC than with CHD, and equally strong relationships in every age group between 45 and 74 years of age.