The lectin binding and targetable cellular uptake of lipid-coated polysaccharide microcapsules
The lectin binding and targetable cellular uptake of lipid-coated polysaccharide microcapsules
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DOI：
10.1039/b920469p
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发表时间：
2010-01-01
影响因子：
--
通讯作者：
Li, Junbai
中科院分区：
文献类型：
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作者：
Qi, Wei;Wang, Anhe;Li, Junbai
在这项研究中，胶囊/脂质复合系统已被开发用于靶向递送小分子药物（盐酸柔红霉素，DNR）到癌细胞。脂质包衣不仅提供密封屏障以防止包封的药物泄漏，而且还可用作将生物功能性附着到胶囊表面的手段。结合到支持的脂质膜中的新糖脂在凝集素结合研究（伴刀豆球蛋白A）中显示出高亲和力，而脂质膜中的叶酸连接的脂质提供靶向癌细胞（MCF-7）的功能能力。叶酸靶向胶囊比非靶向胶囊更有效地将DNR递送至MCF-7细胞。该系统提供了一种方法来创建一个仿生传递载体的有效和选择性靶向药物。
In this study, a capsule/lipid composite system has been developed for targeted delivery of small molecular drugs (daunorubicin hydrochloride, DNR) to cancer cells. The lipid coating not only provides a sealed barrier to prevent the leakage of the encapsulated drugs, but also can be used as a means to attach biological functionality to capsule surfaces. A neoglycolipid incorporated into the supported lipid membrane has shown high affinity in lectin binding studies (concanavalin A), while a folate-linked lipid in the lipid membrane provides a functional capacity to target cancer cells (MCF-7). Folate-targeted capsules are much more efficient than the non-targeted capsules in delivering DNR to MCF-7 cells. The system provides a way to create a biomimetic delivery vehicle for the effective and selective targeting of drugs.