Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography
Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography
复制标题
使用谱域光学相干断层扫描进行视网膜脉搏波速度测量
DOI：
10.1002/jbio.201700163
复制
发表时间：
2018-02-01
影响因子：
2.8
通讯作者：
Zhou, Chuanqing
中科院分区：
文献类型：
--
作者：
Li, Qian;Li, Lin;Zhou, Chuanqing
人眼为小动脉脉搏波速度（PWV）的无创测量提供了一个天然窗口。通过测量视网膜PWV，可以评估小动脉的僵硬程度，可以更好地发现早期血管疾病。因此，视网膜PWV测量越来越受到人们的关注。在这项研究中，提出了一种跳跃扫描方法，用于使用光谱域光学相干断层扫描（SD-OCT）无创测量视网膜PWV。跳变扫描方法采用相位分辨多普勒OCT获取脉冲形状。为了实现PWV测量，跳变扫描方法通过瞬态跳变提取脉冲波从原始OCT扫描点到另一个扫描点的传递时间。一名血压正常的年轻受试者测量到的视网膜动脉PWV在20 ~ 30 mm/s之间，这与以往的研究结果一致。作为比较，我们测量了一名年轻的高血压前期人类受试者的PWV为50 mm/s，这与视网膜PWV与血压之间存在强相关性的发现相一致。综上所述，本文提出的跳跃扫描方法将有利于通过人眼窗口研究和诊断血管疾病。
The human eyes provide a natural window for noninvasive measurement of the pulse wave velocity (PWV) of small arteries. By measuring the retinal PWV, the stiffness of small arteries can be assessed, which may better detect early vascular diseases. Therefore, retinal PWV measurement has attracted increasing attention. In this study, a jump-scanning method was proposed for noninvasive measurement of retinal PWV using spectral-domain optical coherence tomography (SD-OCT). The jump-scanning method uses the phase-resolved Doppler OCT to obtain the pulse shapes. To realize PWV measurement, the jump-scanning method extracts the transit time of the pulse wave from an original OCT scanning site to another through a transient jump. The measured retinal arterial PWV of a young human subject with normal blood pressure was in the order of 20 to 30 mm/s, which was consistent with previous studies. As a comparison, PWV of 50 mm/s was measured for a young human subject with prehypertension, which was in accordance with the finding of strong association between retinal PWV and blood pressure. In summary, it is believed the proposed jump-scanning method could benefit the research and diagnosis of vascular diseases through the window of human eyes.