Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy
Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy
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DOI：
10.1016/j.brs.2008.03.001
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发表时间：
2008-04-01
影响因子：
7.7
通讯作者：
Devanand, D. P.
中科院分区：
文献类型：
--
作者：
Sackeim, Harold A.;Prudic, Joan;Devanand, D. P.
背景尽管电休克疗法（ECT）对抑郁症有效，但认知效应限制了它的应用.减少电脉冲的宽度，并通过使用右侧单侧电极放置可能会减少不良认知影响，同时保留efficacy. MethodsIn a double-masked study。我们将90名抑郁症患者随机分配到右侧单侧ECT（6倍癫痫发作阈值）或双侧ECT（2.5倍癫痫发作阈值），使用传统的短脉冲（1.5毫秒）或超短脉冲（0.3毫秒）。在治疗前、治疗中、治疗后即刻、2个月和6个月对抑郁症状和认知进行评估。结果超短时双侧ECT的最终缓解率为35%，而超短时单侧ECT为73%，标准脉宽双侧ECT为65%，标准脉宽单侧ECT为59%（均P
BackgroundAlthough electroconvulive therapy (ECT) in major depression is effective, cognitive effects limit its use. Reducing the width of the electrical pulse and by using the right unilateral electrode placement may decrease adverse cognitive effects, while preserving efficacy.MethodsIn a double-masked study. we randomly assigned 90 depressed patients to right unilateral ECT at 6 times seizure threshold or bilateral ECT at 2.5 times seizure threshold, using either a traditional brief pulse (1.5 milliseconds) or an ultrabrief Pulse (0.3 millisecond). Depressive symptoms and cognition were assessed before, during, and immediately, 2, and 6 months after therapy. Patients who responded were monitored for a 1-year period.ResultsThe final remission rate for ultrabrief bilateral ECT was 35%, compared with 73% for ultrabrief unilateral ECT, 65% for standard pulse width bilateral ECT, and 59% for standard pulse width unilateral ECT (all P