A common polymorphism of uncoupling protein 2 gene is associated with hypertension
A common polymorphism of uncoupling protein 2 gene is associated with hypertension
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DOI：
10.1097/00004872-200401000-00018
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发表时间：
2004-01-01
影响因子：
4.9
通讯作者：
Ogihara, T
中科院分区：
文献类型：
--
作者：
Ji, QH;Ikegami, H;Ogihara, T
目的 导致肥胖的基因也是肥胖相关疾病（例如高血压和 2 型糖尿病）的候选基因。据报道，解偶联蛋白 2 (UCP2) 启动子的功能多态性与白种人的肥胖有关。为了阐明该多态性对肥胖及相关病症的贡献，我们研究了UCP2基因的-866 G/A多态性与肥胖、高血压和2型糖尿病的关联。方法总共对632名无关的日本受试者进行研究：342名2型糖尿病患者（其中158名并发高血压患者）、156名不患有糖尿病的高血压患者和134名对照受试者。通过聚合酶链式反应(PCR)-限制性片段长度多态性(RFLP)测定UCP2的-866 G/A多态性。结果日本人中次要A等位基因的频率显着高于白种人(48.9% vs 37.2%, P = 0.01)。与白种人肥胖显着相关相反，多态性与日本人肥胖无关。然而，该多态性与日本人的高血压显着相关（A 等位基因的频率：高血压患者为 51.8%，正常血压患者为 46.6%，P < 0.05）。不同基因型患者的体重指数（BMI）、空腹胰岛素水平或HOMA-R均无显着差异。结论这些数据表明UCP2基因多态性与高血压相关，提示UCP2作为高血压病因和治疗研究的靶分子的可能性。 (C) 2004 年利平科特·威廉姆斯·威尔金斯。
Objectives The genes responsible for obesity are also candidate genes for obesity-related conditions, such as hypertension and type 2 diabetes. A functional polymorphism in the uncoupling protein 2 (UCP2) promoter has been reported to be associated with obesity in Caucasians. To clarify the contribution of this polymorphism to obesity and related conditions, we studied the association of the -866 G/A polymorphism of the UCP2 gene with obesity, hypertension and type 2 diabetes mellitus.Methods A total of 632 unrelated Japanese subjects were studied: 342 type 2 diabetic patients (among them, 158 patients complicated with hypertension), 156 hypertensive patients without diabetes mellitus and 134 control subjects. The -866 G/A polymorphism of UCP2 was determined by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).Results The frequency of the minor A allele was significantly higher in Japanese than in Caucasians (48.9 versus 37.2%, P = 0.01). In contrast to the significant association with obesity in Caucasians, the polymorphism was not associated with obesity in Japanese. The polymorphism, however, was significantly associated with hypertension in Japanese (frequency of A allele: 51.8% in hypertensives versus 46.6% in normotensives, P < 0.05). No significant difference was observed in body mass index (BMI), fasting insulin level or HOMA-R between patients with different genotypes.Conclusion These data indicate that the polymorphism of the UCP2 gene is associated with hypertension, and suggest the possibility of UCP2 as a target molecule for studies on the etiology and treatment of hypertension. (C) 2004 Lippincott Williams Wilkins.