Spherical Caps in Cell Polarization
Spherical Caps in Cell Polarization
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DOI：
10.1016/j.bpj.2018.05.033
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发表时间：
2018-07-03
影响因子：
3.4
通讯作者：
Shvartsman, Stanislav Y.
中科院分区：
文献类型：
--
作者：
Diegmiller, Rocky;Montanelli, Hadrien;Shvartsman, Stanislav Y.
细胞内对称性破缺在单细胞和多细胞生物体的许多生物学过程中起着重要的作用。一类重要的破膜机制依赖于蛋白质的细胞质/膜再分布，这些蛋白质可以自催化地促进其自身向质膜的募集。我们提出了一个解析结构和一个全面的参数分析稳定的本地化模式的反应扩散模型，这样的机制在一个球形细胞。所构建的模式采取高浓度补丁的形式定位到球冠中，类似于在单细胞和早期胚胎对称性破缺研究中观察到的模式。
Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.