Genetic variation in recombination rate in the pig.
Genetic variation in recombination rate in the pig.
复制标题
猪重组率的遗传变异。
DOI：
10.1186/s12711-021-00643-0
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发表时间：
2021-06-25
期刊：
影响因子：
--
通讯作者：
Hickey JM
中科院分区：
文献类型：
--
作者：
Johnsson M;Whalen A;Ros-Freixedes R;Gorjanc G;Chen CY;Herring WO;de Koning DJ;Hickey JM
减数分裂重组导致同源染色体之间的遗传物质交换。突变率在基因组的不同部分之间、在个体之间变化，并且受遗传学的影响。在本文中，我们评估了重组率的遗传变异沿着基因组和个体之间的猪使用多位点迭代剥离150,000个人在9个基因型谱系。我们使用这些数据来估计重组的遗传力，并在猪中进行重组的全基因组关联研究。我们的研究结果证实了猪基因组重组景观的已知特征，包括染色体遗传长度的差异和显著的性别差异。重组景观是可重复的线之间，但同时，有不同的平均常染色体全重组率线之间。全常染色体重组率的遗传力很低，但不为零（女性平均为0.07，男性平均为0.05）。我们发现了6个与重组率相关的基因组区域，其中5个含有已知的参与重组的候选基因：RNF 212，SHOC 1，SYCP 2，MSH 4和HFM 1。我们的研究结果在猪基因组中的重组率的变化与其他脊椎动物的报告，具有较低的，但非零的遗传力，并确定一个主要的数量性状位点的重组率是同源的，在其他几个物种中检测到的。这项工作还强调了使用大规模牲畜数据来了解生物过程的实用性。在线版本包含补充材料，可通过10.1186/s12711-021-00643-0获得。
Meiotic recombination results in the exchange of genetic material between homologous chromosomes. Recombination rate varies between different parts of the genome, between individuals, and is influenced by genetics. In this paper, we assessed the genetic variation in recombination rate along the genome and between individuals in the pig using multilocus iterative peeling on 150,000 individuals across nine genotyped pedigrees. We used these data to estimate the heritability of recombination and perform a genome-wide association study of recombination in the pig. Our results confirmed known features of the recombination landscape of the pig genome, including differences in genetic length of chromosomes and marked sex differences. The recombination landscape was repeatable between lines, but at the same time, there were differences in average autosome-wide recombination rate between lines. The heritability of autosome-wide recombination rate was low but not zero (on average 0.07 for females and 0.05 for males). We found six genomic regions that are associated with recombination rate, among which five harbour known candidate genes involved in recombination: RNF212, SHOC1, SYCP2, MSH4 and HFM1. Our results on the variation in recombination rate in the pig genome agree with those reported for other vertebrates, with a low but nonzero heritability, and the identification of a major quantitative trait locus for recombination rate that is homologous to that detected in several other species. This work also highlights the utility of using large-scale livestock data to understand biological processes. The online version contains supplementary material available at 10.1186/s12711-021-00643-0.
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