T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role.
T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role.
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浸润肿瘤和动脉粥样硬化斑块的 T 淋巴细胞产生肝素结合表皮生长因子样生长因子和碱性成纤维细胞生长因子：潜在的病理作用。
DOI：
10.1073/pnas.92.14.6547
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发表时间：
1995
影响因子：
11.1
通讯作者：
Eberlein,TJ
中科院分区：
文献类型：
--
作者：
Peoples,GE;Blotnick,S;Takahashi,K;Freeman,MR;Klagsbrun,M;Eberlein,TJ
尽管T淋巴细胞在肿瘤和动脉粥样硬化斑块中有明显的浸润，但T淋巴细胞在这些病理条件下的作用仍不清楚。我们通过免疫组织化学染色证实，肿瘤浸润性淋巴细胞(TILs)和斑块浸润性淋巴细胞(PILs)在体外非特异性条件下产生肝素结合的表皮生长因子样生长因子(HB-EGF)和碱性成纤维细胞生长因子(BFGF)。TIL和PILs来源的HB-EGF和bFGF分别在体外直接刺激肿瘤细胞和血管平滑肌细胞(SMCs)，而bFGF具有血管生成特性。因此，T细胞可能在动脉粥样硬化的SMC增殖中起关键作用，并通过直接刺激和血管生成来支持肿瘤的发展。
Despite significant infiltration into tumors and atherosclerotic plaques, the role of T lymphocytes in these pathological conditions is still unclear. We have demonstrated that tumor-infiltrating lymphocytes (TILs) and plaque-infiltrating lymphocytes (PILs) produce heparin-binding epidermal growth factor-like growth factor (HB-EGF) and basic fibroblast growth factor (bFGF) in vitro under nonspecific conditions and in vivo in tumors by immunohistochemical staining. HB-EGF and bFGF derived from TILs and PILs directly stimulated tumor cells and vascular smooth muscle cells (SMCs) in vitro, respectively, while bFGF displayed angiogenic properties. Therefore, T cells may play a critical role in the SMC hyperplasia of atherosclerosis and support tumor progression by direct stimulation and angiogenesis.