Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis
Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis
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DOI：
10.1128/iai.00732-06
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发表时间：
2007-01-01
影响因子：
3.1
通讯作者：
Kalams, Spyros A.
中科院分区：
文献类型：
--
作者：
Drake, Wonder P.;Dhason, Mary S.;Kalams, Spyros A.
结节病是一种神秘的疾病，其病理与肺结核相似。我们从15/26结节病患者、1/24纯化蛋白衍生物阴性（PPD-） （P < 0.0001， Fisher精确检验）和7/8 PPD阳性（PPD+）患者的外周血单个核细胞中检测到Th-1对结核分枝杆菌ESAT-6和KatG肽的免疫应答（P = 0.21）。这一发现提供了分枝杆菌和系统性结节病之间的免疫学联系。
Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD-) (P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis.