dMyc transforms cells into super-competitors
dMyc transforms cells into super-competitors
复制标题
DOI：
10.1016/s0092-8674(04)00262-4
复制
发表时间：
2004-04-02
期刊：
影响因子：
64.5
通讯作者：
Basler, K
中科院分区：
文献类型：
--
作者：
Moreno, E;Basler, K
myc原癌基因的过度表达与许多人类肿瘤的发生有关。Myc蛋白似乎调节多种生物过程，但其在肿瘤发生中的作用仍然是谜。在这里，我们使用果蝇图像盘来模拟具有不同水平的Myc蛋白的细胞被对抗的情况，并表明这总是引起一种让人想起细胞竞争的输赢局面；dMyc水平较低的细胞通过凋亡被消除，而dMyc水平较高的细胞过度增殖。我们发现这种竞争行为与BMP/Dpp生存信号通路的激活相关，并且可以通过激活BMP/Dpp生存信号通路来纠正。因此，可遗传的dMyc水平的增加导致细胞表现为“超级竞争者”，并揭示了一种新的克隆扩增模式，这种模式导致（但也依赖于）杀死周围细胞。
Overexpression of myc protooncogenes has been implicated in the genesis of many human tumors. Myc proteins seem to regulate diverse biological processes, but their role in tumorigenesis remains enigmatic. Here we use Drosophila imaginal discs to mimic situations in which cells with unequal levels of Myc protein are apposed and show that this invariably elicits a win/lose situation reminiscent of cell competition; cells with lower levels of dMyc are eliminated by apoptosis whereas cells with higher levels of dMyc over-proliferate. We find that this competitive behavior correlates with, and can be corrected by, the activation of the BMP/Dpp survival signaling pathway. Hence the heritable increase in dMyc levels causes cells to behave as "super-competitors" and reveals a novel mode of clonal expansion that causes, but also relies on, the killing of surrounding cells.