Report of the NIH Task Force on Research Standards for Chronic Low Back Pain
Report of the NIH Task Force on Research Standards for Chronic Low Back Pain
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DOI：
10.1016/j.jpain.2014.03.005
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发表时间：
2014-06-01
期刊：
影响因子：
4
通讯作者：
Weinertt, Debra K.
中科院分区：
文献类型：
--
作者：
Deyo, Richard A.;Dworkin, Samuel F.;Weinertt, Debra K.
尽管干预措施迅速增加，但近几十年来，慢性下腰痛(CLBP)导致的功能障碍有所增加。我们经常找不到机制来解释cLBP对患者生活的主要负面影响。这种cLBP通常被称为非特异性的，可能是由多种生物和行为病因引起的。研究人员使用不同的纳入标准、定义、基线评估和结果衡量标准，这阻碍了比较和共识。因此，NIH疼痛联盟委托一个研究工作组(RTF)起草关于cLBP的研究标准。由此产生的多学科小组建议使用两个问题来定义cLBP；根据其影响(由疼痛强度、疼痛干扰和身体功能定义)；使用最小数据集来描述研究参与者(主要利用PROMIS方法)；除了平均结果得分外，还报告“应答者分析”；以及对未来研究和传播的建议。疼痛联盟已经批准了这些建议，调查人员应该将其纳入NIH的拨款提案中。RTF相信，这些建议将推动这一领域的发展，有助于解决争议，并促进未来解决慢性下腰痛的基因组、神经学和其他机械基础的研究。我们期待RTF的建议将成为一份动态的文件并不断改进。观点：NIH疼痛联盟召集了一个特别工作组，目标是制定慢性下腰痛的研究标准。结果包括对定义、最小数据集、报告结果和未来研究的建议。报告的更大一致性应该有助于研究之间的比较和表型的发展。(C)2014年，由美国疼痛协会发布。由Elsevier Inc.出版。保留所有权利
Despite rapidly increasing intervention, functional disability due to chronic low back pain (cLBP) has increased in recent decades. We often cannot identify mechanisms to explain the major negative impact cLBP has on patients' lives. Such cLBP is often termed non-specific and may be due to multiple biologic and behavioral etiologies. Researchers use varied inclusion criteria, definitions, baseline assessments, and outcome measures, which impede comparisons and consensus. Therefore, NIH Pain Consortium charged a Research Task Force (RTF) to draft standards for research on cLBP. The resulting multidisciplinary panel recommended using 2 questions to define cLBP; cLBP by its impact (defined by pain intensity, pain interference, and physical function); use of a minimum dataset to describe research participants (drawing heavily on the PROMIS methodology); reporting "responder analyses" in addition to mean outcome scores; and suggestions for future research and dissemination. The Pain Consortium has approved the recommendations, which investigators should incorporate into NIH grant proposals. The RTF believes that these recommendations will advance the field, help to resolve controversies, and facilitate future research addressing the genomic, neurologic, and other mechanistic substrates of chronic low back pain. We expect that the RTF recommendations will become a dynamic document and undergo continual improvement.Perspective: A task force was convened by the NIH Pain Consortium with the goal of developing research standards for chronic low back pain. The results included recommendations for definitions, a minimum dataset, reporting outcomes, and future research. Greater consistency in reporting should facilitate comparisons among studies and the development of phenotypes. (C) 2014 by the American Pain Society. Published by Elsevier Inc. All rights reserved