Adverse reactions to contrast media: related to medium or procedure? Observations on a case.
Adverse reactions to contrast media: related to medium or procedure? Observations on a case.
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造影剂的不良反应：与介质或程序有关？
DOI：
10.1259/0007-1285-61-724-337
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
H. Stormorken
中科院分区：
文献类型：
--
作者：
J. Hald;J. Jakobsen;E. Andrew;H. Stormorken
血管内造影剂的不良反应已有充分记录（Andrews，1974; Ansell，1976; Lalli，1980; Shehadi & Toniolo，1980）。然而，对药物的过敏和毒性反应必须与手术的不良反应区分开来。为了说明这一点，我们报告如下。在一项I期耐受性和药代动力学研究中，将碘戊醇（Nyapentol AS）（一种新型3.0非离子造影剂）注射至24名健康男性志愿者体内（Aakhus等人，1987）。作为研究的一部分，8名受试者静脉注射生理盐水。其中一名志愿者是一名30岁的健康男性。在试验当天，开始向左肘静脉注射生理盐水后约30 s，发生不良反应（表I）。受试者变得苍白和头晕。静脉穿刺后3分钟，血压降至69/45 mm Hg，心电图（ECG）显示无P波。心率略有下降，脉搏微弱。病情逐渐…
Adverse reactions to intravascular contrast media are well documented (Andrews, 1974; Ansell, 1976; Lalli, 1980; Shehadi & Toniolo, 1980). However, allergic and toxic reactions to drugs have to be differentiated from adverse reactions to the procedure. To illustrate this, we report the following. In a Phase I tolerance and pharmacokinetic study, iopentol (Nycomed AS), a new 3.0 non-ionic contrast medium, was to be injected into 24 healthy male volunteers (Aakhus et al, 1987). As part of the study, eight subjects received normal saline intravenously. One of the volunteers was a 30-year-old healthy male. On the trial day, approximately 30 s after the start of the injection of normal saline into his left cubital vein, an adverse reaction occurred (Table I). The subject became pale and dizzy. Three minutes after venepuncture, the blood pressure had fallen to 69/45 mm Hg and the electrocardiogram (ECG) showed absence of the P-wave. The heart rate dropped slightly and the pulse was weak. The condition gradually...