An Experimental and clinical evaluation of immuno-modulating potential of human placental extract
An Experimental and clinical evaluation of immuno-modulating potential of human placental extract
复制标题
人胎盘提取物免疫调节潜力的实验和临床评价
DOI：
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发表时间：
1994
影响因子：
2.4
通讯作者：
S. Bapat
中科院分区：
文献类型：
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作者：
K. Ansari;Gupta Nira;S. Bapat
研究了人胎盘提取物（placentrex）对兔子和人类志愿者免疫系统的影响。在兔子中使用伤寒-H 抗原和 DNCB 和结核菌素皮肤敏感性进行 Widal 凝集试验，作为体液和细胞介导的免疫的测量。在人类志愿者中，使用三抗原板通过免疫球蛋白（IgG、IgM 和 IgA）估计来评估体液免疫，并通过总淋巴细胞计数和 T 细胞计数来评估细胞介导的免疫。在拉比中观察到 H 抗体滴度显着升高，并且对 DNCB 和结核菌素的敏感性等级增加。同样，在人类受试者中观察到血清免疫球蛋白以及总淋巴细胞和 T 细胞计数的增加。这些结果表明胎盘对动物和人类受试者的体液和细胞介导的免疫具有免疫刺激作用。这一发现对于恢复 B 细胞和 T 细胞淋巴细胞的功能障碍可能具有巨大意义。
Effect of human placental extract (placentrex) was investigated on immune system of rabbits as well as human volunteers. In rabbits widal agglutination test using typhoid-H antigen and DNCB & tuberculin skin sensitivity were performed as measurement of humoral and cell mediated immunity. In human volunteers humoral immunity was evaluated by immunoglobulin (IgG, IgM and IgA) estimation using tripantigen plates and the cell mediated immunity was assessed by total lymphocyte count and Tcell counts. In rabbis significant rise in H-antibody titre and increase in grades of sensitivity against DNCB and tuberculin were observed. Likewise in human subjects an increase in serum immunoglobulin as well as total lymphocyte and T-cell counts were observed. These results suggest that placentrex is immunostimulant for humoral and cell mediated immunity in animals as well as human subjects. The finding may be of immense significance for restoring dysfunction of B and T cell lymphocytes.