Fibronectins: multifunctional modular glycoproteins.
Fibronectins: multifunctional modular glycoproteins.
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DOI：
10.1083/jcb.95.2.369
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发表时间：
1982-11
期刊：
影响因子：
--
通讯作者：
Yamada KM
中科院分区：
文献类型：
--
作者：
Hynes RO;Yamada KM
纤维连接蛋白是一种大的糖蛋白，与多种细胞特性有关，特别是那些涉及细胞与细胞外物质相互作用的特性。这些特性包括细胞黏附、形态、细胞骨架组织、迁移、分化、致癌转化、吞噬和止血。在过去的几年里，许多实验室的研究分析了纤维连接蛋白的表达、功能和结构。这些研究表明，纤维连接蛋白具有由多个特定结合位点组成的复杂分子结构，现在可以从这个结构来考虑纤维连接蛋白参与的复杂生物学现象。在这篇简短的文章中，我们将回顾目前对纤维粘连蛋白结构和性质的了解。由于已经发表了许多关于纤维粘连蛋白各个方面的综合综述(1-13)，我们将重点介绍这一迅速扩展的领域的总体概念、最新进展和前景广阔的未来研究方向。
Fibronectins are large glycoproteins that have been implicated in a wide variety of cellular properties, particularly those involving the interactions of cells with extracellular materials. These properties include cell adhesion, morphology, cytoskeletal organization, migration, differentiation, oncogenic transformation, phagocytosis, and hemostasis. During the past several years, investigations in many laboratories have analyzed the expression, functions, and structure of fibronectins. These studies have revealed that fibronectins have a complex molecular structure consisting of multiple specific binding sites, and the complex biological phenomena in which fibronectins participate can now be considered in terms of this structure. In this brief article we will review the current understanding of the structure and properties of fibronectins. Because a number of comprehensive reviews on various aspects of fibronectins have been published (1-13), we shall focus on overall concepts, recent developments and promising future research directions in this rapidly expanding field.