Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers
Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers
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DOI：
10.1016/j.jconrel.2007.03.022
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发表时间：
2007-08-16
影响因子：
10.8
通讯作者：
Mitragotri, Samir
中科院分区：
文献类型：
--
作者：
Champion, Julie A.;Katare, Yogesh K.;Mitragotri, Samir
将治疗剂包封在聚合物颗粒中已成功地用于开发新的药物载体。许多控制载体功能行为的设计参数，包括聚合物的选择，粒径和表面化学，已经被调整以优化其在体内的性能。然而，颗粒形状，这也可能有很大的影响载体的性能，尚未得到彻底的研究。这可能是由于生产非球形聚合物颗粒的技术有限。近年来，已经出现了许多直接解决这一瓶颈的报告，初步研究确实证实了颗粒形状可以显着影响聚合物药物载体的性能。本文综述了该领域的颗粒制备方法和颗粒形状在药物释放中的作用。(C)2007 Elsevier B.V.保留所有权利。
Encapsulation of therapeutic agents in polymer particles has been successfully used in the development of new drug carriers. A number of design parameters that govern the functional behavior of carriers, including the choice of polymer, particle size and surface chemistry, have been tuned to optimize their performance in vivo. However, particle shape, which may also have a strong impact on carrier performance, has not been thoroughly investigated. This is perhaps due to the limited availability of techniques to produce non-spherical polymer particles. In recent years, a number of reports have emerged to directly address this bottleneck and initial studies have indeed confirmed that particle shape can significantly impact the performance of polymer drug carriers. This article provides a review of this field with respect to methods of particle preparation and the role of particle shape in drug delivery. (C) 2007 Elsevier B.V. All rights reserved.