Effect of melatonin on circadian rhythm, locomotor activity and body temperature in the intact house sparrow, Japanese quail and owl
Effect of melatonin on circadian rhythm, locomotor activity and body temperature in the intact house sparrow, Japanese quail and owl
复制标题
DOI：
10.1016/s0006-8993(00)03205-4
复制
发表时间：
2001-01
期刊：
影响因子：
2.9
通讯作者：
N. Murakami;Takanori Kawano;K. Nakahara;T. Nasu;K. Shiota
中科院分区：
文献类型：
--
作者：
N. Murakami;Takanori Kawano;K. Nakahara;T. Nasu;K. Shiota
我们比较了褪黑激素对完整家雀、日本鹌鹑和猫头鹰的昼夜节律、体温和运动的影响。每天在固定的时间与褪黑激素治疗并没有夹带自由运行的运动活动的节律在家雀和日本鹌鹑在恒定的昏暗的灯光下打乱节奏。然而，褪黑激素在治疗后几个小时明显抑制运动。注射褪黑激素后的静息时间呈剂量依赖性。褪黑激素治疗后，体温显着下降，效果更有效的活动期比在休息期。虽然褪黑激素对体温的影响也是剂量依赖性的，但注射褪黑激素后体温下降的幅度在家雀中比在日本鹌鹑中更大。另一方面，褪黑激素诱导了夜间活动的鸟类猫头鹰体温的进一步大幅下降，猫头鹰的松果体已经退化。活动期体温下降幅度大于静息期，且褪黑激素不能阻止体温下降的运动。这些结果表明，褪黑激素对昼夜节律，运动活动和体温的影响在鸟类物种之间存在差异，并且这些机制可能彼此无关。
We compared the effect of melatonin on circadian rhythm, body temperature, and locomotion in the intact house sparrow, Japanese quail and owl. Daily treatment with melatonin at a fixed time did not entrain the free-running rhythm of locomotor activity in the house sparrow and the disrupted rhythm in Japanese quail under constant dim light. However, melatonin clearly inhibited movement for several hours after treatment. The duration of resting after injection of melatonin was dose-dependent. Body temperature was significantly decreased after melatonin treatment, the effect being more potent during the active phase than in the resting phase. Although this effect of melatonin on body temperature was also dose-dependent, the magnitude of the decrease in body temperature after injection of melatonin was greater in the house sparrow than in the Japanese quail. On the other hand, melatonin induced a further large decrease of body temperature in a nocturnal bird, the owl, whose pineal gland is degenerate. The decrease of body temperature was larger in the active phase than in the resting phase, and melatonin did not prevent movement in spite of the decrease in body temperature. These results suggest that the effects of melatonin on circadian rhythm, locomotor activity and body temperature differ among avian species, and that these mechanisms may not be linked to each other.