NEURONAL REPAIR Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
NEURONAL REPAIR Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
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DOI：
10.1126/science.1253050
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发表时间：
2014-06-13
期刊：
影响因子：
56.9
通讯作者：
Schwab, M. E.
中科院分区：
文献类型：
--
作者：
Wahl, A. S.;Omlor, W.;Schwab, M. E.
中风后，大脑自发恢复丧失的运动功能的能力有限。康复是临床上普遍采用的增强功能恢复的方法，但其科学基础却知之甚少。在这里，我们展示了在大中风大鼠中，当应用针对轴突生长抑制蛋白的促生长免疫疗法来促进新纤维的萌发，然后通过强化训练稳定新形成的神经回路时，熟练的前肢功能几乎完全恢复。相比之下，生长阶段早期的高强度训练破坏了这种效果，并导致了纤维图案的异常。药物遗传学实验发现，皮质脊髓纤维的一个子集起源于前脑的完整一半，在脊髓中进行侧向切换，以新的神经支配受损的肢体，恢复熟练的运动功能。
The brain exhibits limited capacity for spontaneous restoration of lost motor functions after stroke. Rehabilitation is the prevailing clinical approach to augment functional recovery, but the scientific basis is poorly understood. Here, we show nearly full recovery of skilled forelimb functions in rats with large strokes when a growth-promoting immunotherapy against a neurite growth-inhibitory protein was applied to boost the sprouting of new fibers, before stabilizing the newly formed circuits by intensive training. In contrast, early high-intensity training during the growth phase destroyed the effect and led to aberrant fiber patterns. Pharmacogenetic experiments identified a subset of corticospinal fibers originating in the intact half of the forebrain, side-switching in the spinal cord to newly innervate the impaired limb and restore skilled motor function.