Complex decisions in managing HIV infection during pregnancy.
Complex decisions in managing HIV infection during pregnancy.
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DOI：
10.1007/s11904-011-0077-5
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发表时间：
2011-06-01
影响因子：
4.6
通讯作者：
Wright, Rodney
中科院分区：
文献类型：
--
作者：
Vogler, Mary A;Singh, Harjot;Wright, Rodney
世界卫生组织和美国卫生与公众服务部最近根据新出现的数据，其中大部分来自发展中国家，对围产期艾滋病毒治疗准则进行了大幅修订。妊娠和分娩期间艾滋病毒感染的管理因对母体和胎儿药物毒性、获得抗逆转录病毒耐药性、既往治疗、与其他病毒合并感染以及偶然机会性感染的担忧而变得复杂。在产妇感染艾滋病毒的情况下，分娩期间和分娩前后的产科管理，包括剖腹产的作用，继续发生变化。最后，新的数据扩大了抗病毒治疗的作用，使资源有限的环境中感染艾滋病毒的母亲能够选择更安全的婴儿喂养。
Both the World Health Organization and the United States Department of Health and Human Services have recently substantially revised perinatal HIV treatment guidelines based on emerging data, much of it from the developing world. Management of HIV infection in pregnancy and delivery is complicated by concerns for maternal and fetal drug toxicity, acquisition of antiretroviral resistance, prior therapy, co-infections with other viruses, as well as incident opportunistic infections. Intrapartum and peripartum obstetric management, including the role of Caesarean section, continue to evolve in the setting of maternal HIV infection. Finally, new data have expanded the role of antiviral therapy in allowing safer infant feeding choices for HIV-infected mothers in resource-limited settings.