The effect of Epstein-Barr virus status on outcome in age- and sex-defined subgroups of patients with advanced Hodgkin's disease
The effect of Epstein-Barr virus status on outcome in age- and sex-defined subgroups of patients with advanced Hodgkin's disease
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DOI：
10.1093/annonc/mdg065
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发表时间：
2003-02-01
影响因子：
50.5
通讯作者：
Murray, PG
中科院分区：
文献类型：
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作者：
Flavell, KJ;Billingham, LJ;Murray, PG
背景资料：关于EB病毒（EBV）对何杰金氏病（HD）结局影响的证据可能是由于这种疾病的异质性。在这项研究中，我们已经调查了EBV状态对结果的影响是否是不同的病因定义的年龄组之间（15-34，35-44，45+岁），也在男性和女性之间。患者和方法：石蜡包埋的部分从273例先进的HD从两个相关的临床试验进行了分析，EB病毒的存在使用它？结果：EBV阳性78例（29%）。对于所有患者，中位随访5年后，EBV状态的生存率无显著差异，尽管EBV阳性患者的无失败生存时间有延长的趋势。多变量分析表明，EBV和性别，在组合时，无失败生存的预后因素（P = 0.06）。对于亚组，男性和15-34岁年龄组（P = 0.05和P = 0.03，分别）EBV对无失败生存率的影响是显着的：结论：这项研究表明，与中位随访5年，EBV状态不影响生存，但EBV阳性可能是有益的无失败生存，特别是男性和年轻人。
Background: Conflicting data on the effect of the Epstein-Barr virus (EBV) on outcome in Hodgkin's disease (HD) might be due to the heterogeneous nature of this disease. In this study we have investigated whether the effect of EBV status on outcome is different between aetiologically defined age groups (15-34, 35-44, 45+ years) and also between males and females.Patients and methods: Paraffin-embedded sections from 273 patients with advanced HD from two related clinical trials were analysed for the presence of EBV using it? situ hybridisation.Results: EBV was detected in 78 (29%) of cases. For all patients, after a median follow-up of 5 years, there were no significant differences in survival by EBV status although there was a trend towards longer failure-free survival times for EBV-positive patients. Multivariate analyses suggested that EBV and sex, when in combination, were prognostic factors for failure-free survival (P = 0.06 for both). For subgroups, the effect of EBV on failure-free survival was significant for males and 15-34 years age group (P = 0.05 and P = 0.03, respectively).Conclusion: This study suggests that with a median follow-up of 5 years, EBV status does not affect survival but being EBV-positive may be beneficial in terms of failure-free survival, particularly for males and younger adults.