Effect of cerebrospinal fluid hyperosmolality on sweating in the heat-stressed patas monkey.
Effect of cerebrospinal fluid hyperosmolality on sweating in the heat-stressed patas monkey.
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脑脊液高渗透压对热应激帕塔猴出汗的影响。
DOI：
10.1152/jappl.1989.67.1.128
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Gisolfi,CV
中科院分区：
文献类型：
--
作者：
Owen,MD;Matthes,RD;Gisolfi,CV
在热应激期间，脱水增加体液的渗透压并降低出汗率。通过将渗透压刺激定位于中枢神经系统组织，本研究评估了中枢刺激对热应激非人灵长类动物出汗的作用。在向第三脑室输注（255-413微升）高渗人工脑脊液（ACSF）期间，监测暴露于41 +/- 2 ℃的伦哌隆镇静的patas猴（红猴n = 5）的小腿出汗率、直肠和平均皮肤温度、耗氧量和心率。与对照ACSF（285 mosmol/kgH 2 O）相比，ACSF用NaCl进行高渗，以产生800和1，000 mosmol/kgH 2 O的渗透压，显著降低出汗率，在输注期间分别达到37%和53%的最大降低。在恢复期，直肠温度显著升高，在输注后20分钟分别升高0.69和0.72 ℃。与此相反，ACSF高渗蔗糖（800 mosmol/kgH 2 O）未能改变出汗率或直肠温度输注期间在三只动物。因此，高渗ACSF的脑室内输注模拟了脱水诱导的体温调节作用。输注期间热损失的减少似乎取决于脑脊液[Na+]的升高，而不是渗透压摩尔浓度本身。
Dehydration increases the osmolality of body fluids and decreases the rate of sweating during thermal stress. By localizing osmotic stimuli to central nervous system tissues, this study assessed the role of central stimulation on sweating in a heat-stressed nonhuman primate. Lenperone-tranquilized patas monkeys (Erythrocebus patas n = 5), exposed to 41 +/- 2 degrees C, were monitored for calf sweat rate, rectal and mean skin temperatures, oxygen consumption, and heart rate during infusions (255–413 microliters) of hypertonic artificial cerebrospinal fluid (ACSF) into the third cerebral ventricle. ACSF made hypertonic with NaCl to yield osmolalities of 800 and 1,000 mosmol/kgH2O significantly decreased sweat rate compared with control ACSF (285 mosmol/kgH2O), achieving maximal reductions during infusion of 37 and 53%, respectively. Rectal temperature significantly increased during the recovery period, reaching elevations of 0.69 and 0.72 degrees C, respectively, at 20 min postinfusion. In contrast, ACSF made hypertonic with sucrose (800 mosmol/kgH2O) failed to change sweat rate or rectal temperature during infusion in three animals. Thus, intracerebroventricular infusions of hypertonic ACSF mimicked dehydration-induced effects on thermoregulation. The reduction in heat loss during infusion appeared to depend on an elevation in cerebrospinal fluid [Na+] and not osmolality per se.