The mirror neuron system also rests
The mirror neuron system also rests
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DOI：
10.1007/s00429-016-1335-5
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发表时间：
2017-07-01
影响因子：
3.1
通讯作者：
Luis Gonzales-Mora, Jose
中科院分区：
文献类型：
--
作者：
Plata-Bello, Julio;Modrono, Cristian;Luis Gonzales-Mora, Jose
镜像神经元系统（MNS）是一种大脑网络，与理解他人的行为有关。被认为属于MNS的大脑的主要区域是下顶叶（IPL）的喙部和额下回（IFG）。许多研究试图集中在MNS所属区域之间的关系，但很少考虑静息状态下MNS的研究。在本实验中，MNS已经研究了两种功能磁共振成像模式（基于任务的fMRI和静息fMRI）和三个分析程序[任务块比较，功能连接（FC），独立成分分析（伊卡）]。区组设计的任务功能磁共振成像显示，位于头侧IPL的镜像活动。该局部最大体素的坐标被定义为用于静息fMRI的FC分析的感兴趣区域（ROI）。该分析揭示了形成MNS网络核心的区域内以及与具有镜像性质的其他区域的功能连接的存在。最后，静息态fMRI伊卡显示了相同的功能网络，尽管它更局限于核心MNS区域。据我们所知，这是第一个研究方法的MNS使用静息态功能磁共振成像分析，独立成分分析和功能连接在同一时间。
The mirror neuron system (MNS) is a brain network that has been associated with the understanding of the actions performed by others. The main areas of the brain that are considered as belonging to the MNS are the rostral part of the inferior parietal lobe (IPL) and the inferior frontal gyrus (IFG). Many studies have tried to focus on the relationship between the regions belonging to the MNS, but a little consideration has been given to the study of the MNS in resting conditions. In the present experiment, the MNS has been studied by two fMRI modalities (task-based fMRI and resting-fMRI) and three analytical procedures [task-block comparison, functional connectivity (FC), and independent component analysis (ICA)]. The task-fMRI with block design showed a mirror activity located in the rostral IPL. The coordinates of this local maximum voxel were defined as a region of interest (ROI) for an FC analysis of the resting-fMRI. This analysis revealed the existence of a functional connectivity within regions forming the core of MNS network and also with other regions with mirror properties. Finally, resting-state fMRI ICA showed the same functional network, although it was more restricted to the core MNS regions. To the best of our knowledge, this is the first study that approaches the MNS using the resting-state fMRI analysis using independent component analysis and functional connectivity at the same time.