Impaired familiarity with preserved recollection after anterior temporal-lobe resection that spares the hippocampus
Impaired familiarity with preserved recollection after anterior temporal-lobe resection that spares the hippocampus
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DOI：
10.1073/pnas.0705273104
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发表时间：
2007-10-09
影响因子：
11.1
通讯作者：
Kohler, Stefan
中科院分区：
文献类型：
--
作者：
Bowles, Ben;Crupi, Carina;Kohler, Stefan
众所周知，内侧颞叶（MTL）是识别记忆的关键。已知MTL由以分层方式组织的不同结构组成。目前，这一层次结构中的较低结构（如嗅周皮层）是否支持与较高结构（特别是海马体）不同的记忆功能仍存在争议。嗅周皮层被认为在识别过程中对熟悉性的评估中起着特定的作用，这可以与海马体对情景细节回忆的选择性贡献区分开来。然而，一些研究人员认为，熟悉和回忆之间的区别不能捕捉MTL内的功能专业化，并提出了单过程帐户。支持双加工观点的证据来自于选择性海马损伤可以产生孤立的回忆障碍。然而，颞叶损伤是否会造成选择性的熟悉性损伤，而海马体却不受影响，这一点还不清楚。如果没有这个演示，就不能排除单进程帐户。我们研究了NB的识别记忆，NB是一个接受左前颞叶结构手术切除治疗顽固性癫痫的患者。她的切除包括大部分的嗅周皮质，但保留了海马体。四个实验的结果基于三个不同的实验程序（记住知道范式，接收器操作特性，和响应截止日期程序）表明，NB表现出受损的熟悉与保存的回忆。因此，目前的研究结果提供了一个关键的支持功能专业化的MTL缺失的一块。
It is well established that the medial-temporal lobe (MTL) is critical for recognition memory. The MTL is known to be composed of distinct structures that are organized in a hierarchical manner. At present, it remains controversial whether lower structures in this hierarchy, such as perirhinal cortex, support memory functions that are distinct from those of higher structures, in particular the hippocampus. Perirhinal cortex has been proposed to play a specific role in the assessment of familiarity during recognition, which can be distinguished from the selective contributions of the hippocampus to the recollection of episodic detail. Some researchers have argued, however, that the distinction between familiarity and recollection cannot capture functional specialization within the MTL and have proposed single-process accounts. Evidence supporting the dual-process view comes from demonstrations that selective hippocampal damage can produce isolated recollection impairments. It is unclear, however, whether temporal-lobe lesions that spare the hippocampus can produce selective familiarity impairments. Without this demonstration, single-process accounts cannot be ruled out. We examined recognition memory in NB, an individual who underwent surgical resection of left anterior temporal-lobe structures for treatment of intractable epilepsy. Her resection included a large portion of perirhinal cortex but spared the hippocampus. The results of four experiments based on three different experimental procedures (remember-know paradigm, receiver operating characteristics, and response-deadline procedure) indicate that NB exhibits impaired familiarity with preserved recollection. The present findings thus provide a crucial missing piece of support for functional specialization in the MTL.