B cell immunology for the clinician.
B cell immunology for the clinician.
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临床医生的 B 细胞免疫学。
DOI：
10.1097/inf.0b013e318207447f
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Anolik,JenniferH
中科院分区：
文献类型：
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作者：
Marcus,Carolina;Dhillon,Gitika;Anolik,JenniferH
B淋巴细胞在维持健康方面起着关键的保护作用，包括防御感染和对疫苗产生有效的反应。越来越多地，人们认识到B细胞与T淋巴细胞积极相互作用，以促进抗体非依赖性保护和致病功能; B细胞不再被简单地视为“抗体工厂”。B细胞发育缺陷可能与临床免疫缺陷相关，而过度活跃的B细胞区室可能导致自身免疫性疾病、恶性疾病和移植排斥的发生。1–7
B lymphocytes play critical protective roles in maintaining health, including defense against infection and generating an effective response to vaccines. Increasingly, B cells are recognized to actively interact with T lymphocytes to contribute to antibody-independent protective and pathogenic function; B cells are no longer viewed simply as “antibody factories.” Defects in B cell development can be associated with clinical immunodeficiency, whereas a hyperactive B cell compartment may contribute to the development of autoimmune disease, malignant diseases, and transplant rejection. 1–7