Projections of the medial orbital and ventral orbital cortex in the rat
Projections of the medial orbital and ventral orbital cortex in the rat
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DOI：
10.1002/cne.22733
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发表时间：
2011-12-15
影响因子：
2.5
通讯作者：
Vertes, Robert P.
中科院分区：
文献类型：
--
作者：
Hoover, Walter B.;Vertes, Robert P.
眶内侧（MO）和眶腹侧（VO）皮层是眶内侧前额叶皮层的重要分支。据我们所知，在大鼠中没有报道全面描述MO和VO的投影。采用顺行示踪剂Phaseolus vulgaris白细胞凝集素和顺行示踪剂Fluoro-Gold，研究了MO和VO在大鼠体内的传入投射。虽然MO和VO的投影重叠，但MO在整个大脑中的分布更广泛，特别是在边缘结构，而VO则相反。MO的主要皮层靶点是眶皮质、腹侧内侧前额叶皮质、颗粒岛皮质、梨状皮质、脾后皮质和海马旁皮质。MO的主要皮层下靶点为基底前脑内侧纹状体、嗅结节、屏状体、伏隔核、隔隔、无名质、外侧视前区和对角带核；杏仁核的中央核、内侧核、皮质核和基底核；丘脑的幕旁核、中背核和团聚核；下丘脑后核、乳头上核和外侧核；以及导水管周围灰质，腹侧被盖区，黑质，中缝背侧和正中，背侧被盖和脑干的中核。相比之下，VO分布在这些相同的部位，特别是纹状体，但缺乏对边缘皮质，伏隔核和杏仁核的部分投射。然而，VO在内侧（额叶）颗粒皮层、前扣带皮层、感觉运动皮层、后顶叶皮层、外侧颗粒皮层、脾后皮层和颞联合皮层的分布要比MO强烈得多。MO的投影模式与mPFC相似，而VO的投影与腹外侧眶皮质（VLO）的投影重叠。这表明MO的功能与mPFC类似，如目标导向行为，而VO的功能与VLO类似，如定向注意。MO/VO也可能作为眶外侧和内侧前额皮质之间的联系。中国生物医学工程学报，2011,19(5):377 - 381。(c) 2011 Wiley-Liss, Inc。
The medial orbital (MO) and ventral orbital (VO) cortices are prominent divisions of the orbitomedial prefrontal cortex. To our knowledge, no previous report in the rat has comprehensively described the projections of MO and VO. By using the anterograde tracer Phaseolus vulgaris leucoagglutinin and the retrograde tracer Fluoro-Gold, we examined the efferent projections of MO and VO in the rat. Although MO and VO projections overlap, MO distributes more widely throughout the brain, particularly to limbic structures, than does VO. The main cortical targets of MO were the orbital, ventral medial prefrontal (mPFC), agranular insular, piriform, retrosplenial, and parahippocampal cortices. The main subcortical targets of MO were the medial striatum, olfactory tubercle, claustrum, nucleus accumbens, septum, substantia innominata, lateral preoptic area, and diagonal band nuclei of the basal forebrain; central, medial, cortical, and basal nuclei of amygdala; paratenial, mediodorsal, and reuniens nuclei of the thalamus; posterior, supramammillary, and lateral nuclei of the hypothalamus; and periaqueductal gray, ventral tegmental area, substantia nigra, dorsal and median raphe, laterodorsal tegmental, and incertus nuclei of the brainstem. By comparison, VO distributes to some of these same sites, notably to the striatum, but lacks projections to parts of limbic cortex, to nucleus accumbens, and to the amygdala. VO distributes much more strongly, however, than MO to the medial (frontal) agranular, anterior cingulate, sensorimotor, posterior parietal, lateral agranular retrosplenial, and temporal association cortices. The patterns of MO projections are similar to those of the mPFC, whereas the projections of VO overlap with those of the ventrolateral orbital cortex (VLO). This suggests that MO serves functions comparable to those of the mPFC, such as goal-directed behavior, and VO performs functions similar to VLO such as directed attention. MO/VO may also serve as a link between lateral orbital and medial prefrontal cortices. J. Comp. Neurol. 519:37663801, 2011. (c) 2011 Wiley-Liss, Inc.