Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade
Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade
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DOI：
10.1093/nar/27.10.2086
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发表时间：
1999-05-15
影响因子：
14.9
通讯作者：
Latchman, DS
中科院分区：
文献类型：
--
作者：
Liu, YZ;Boxer, LM;Latchman, DS
Bcl-2 蛋白在神经元和其他细胞类型中具有抗凋亡作用。我们首次证明 Bcl-2 启动子是由神经元生存因子神经生长因子 (NGF) 激活的，并且这种效应取决于启动子的 -1472 至 -1414 区域。这种激活需要 Rap-1 G 蛋白以及 MEK-1 和 p42/p44 MAPK 酶，但独立于涉及蛋白激酶 A 或蛋白激酶 C 的其他 NGF 激活信号通路。
The Bcl-2 protein has an anti-apoptotic effect in neuronal and other cell types. We show for the first time that the Bcl-2 promoter is activated by the neuronal survival factor nerve growth factor (NGF) and that this effect is dependent on a region of the promoter from -1472 to -1414. This activation requires the Rap-1 G protein and the MEK-1 and p42/p44 MAPK enzymes but is independent of other NGF-activated signalling pathways involving protein kinase A or protein kinase C.