High Coronary Shear Stress in Patients With Coronary Artery Disease Predicts Myocardial Infarction
High Coronary Shear Stress in Patients With Coronary Artery Disease Predicts Myocardial Infarction
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DOI：
10.1016/j.jacc.2018.07.075
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发表时间：
2018-10-16
影响因子：
24
通讯作者：
Samady, Habib
中科院分区：
文献类型：
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作者：
Kumar, Arnav;Thompson, Elizabeth W.;Samady, Habib
背景：经药物治疗的低血流储备分数（FFR）的冠状动脉病变与较高的血运重建率相关。高壁剪切应力（WSS）已与增加斑块vulnerability.AccurativesThis研究调查的预后价值WSS测量的近段病变（WSSprox）预测心肌梗死（MI）的患者稳定性冠状动脉疾病（CAD）和血流动力学显着病变。作者假设，在低FFR和稳定CAD的患者中，较高的WSSprox可预测MI。方法在FAME II（血流储备分数与血管造影术用于多支血管评价II）试验的441例患者中，
BACKGROUND Coronary lesions with low fractional flow reserve (FFR) that are treated medically are associated with higher revascularization rates. High wall shear stress (WSS) has been linked with increased plaque vulnerability.OBJECTIVES This study investigated the prognostic value of WSS measured in the proximal segments of lesions (WSSprox) to predict myocardial infarction (MI) in patients with stable coronary artery disease (CAD) and hemodynamically significant lesions. The authors hypothesized that in patients with low FFR and stable CAD, higher WSSprox would predict MI.METHODS Among 441 patients in the FAME II (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation II) trial with FFR