COPII-dependent ER export in animal cells: adaptation and control for diverse cargo.
COPII-dependent ER export in animal cells: adaptation and control for diverse cargo.
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DOI：
10.1007/s00418-018-1689-2
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发表时间：
2018-08
影响因子：
2.3
通讯作者：
Stephens DJ
中科院分区：
文献类型：
--
作者：
McCaughey J;Stephens DJ
从内质网输出新合成的蛋白质对于持续维持细胞和组织的结构和功能至关重要。共翻译易位到 ER 后，前往下游细胞内区室或从细胞分泌的蛋白质被 COPII 外壳蛋白复合物分选并包装到运输囊泡中。通过对 COPII 在细胞功能各个方面的作用的更深入了解，该途径的基本发现和表征现已得到加强。我们现在对 COPII 如何促进多种货物的运输有了深入的了解，包括细胞外基质分子、发育信号蛋白和脂蛋白等关键代谢因子。结构和功能研究表明，COPII 涂层既高度灵活，又受多种调节模式的影响。这导致了新的发现，定义了 COPII 在发育、自噬和组织组织中的作用。经典 COPII 途径的许多新出现的特征都被置于前胶原分泌的背景下，因为人们对通常产生 80 nm 运输囊泡的外壳复合物如何包装据报道超过 300 nm 的货物有根本的兴趣。在这里，我们回顾了目前对 COPII 的理解，并评估了目前对其在包装不同货物蛋白中的作用的共识。
The export of newly synthesized proteins from the endoplasmic reticulum is fundamental to the ongoing maintenance of cell and tissue structure and function. After co-translational translocation into the ER, proteins destined for downstream intracellular compartments or secretion from the cell are sorted and packaged into transport vesicles by the COPII coat protein complex. The fundamental discovery and characterization of the pathway has now been augmented by a greater understanding of the role of COPII in diverse aspects of cell function. We now have a deep understanding of how COPII contributes to the trafficking of diverse cargoes including extracellular matrix molecules, developmental signalling proteins, and key metabolic factors such as lipoproteins. Structural and functional studies have shown that the COPII coat is both highly flexible and subject to multiple modes of regulation. This has led to new discoveries defining roles of COPII in development, autophagy, and tissue organization. Many of these newly emerging features of the canonical COPII pathway are placed in a context of procollagen secretion because of the fundamental interest in how a coat complex that typically generates 80-nm transport vesicles can package a cargo reported to be over 300 nm. Here we review the current understanding of COPII and assess the current consensus on its role in packaging diverse cargo proteins.
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