Summer Peaks in Uptake of Human Papillomavirus and Other Adolescent Vaccines in the United States.
Summer Peaks in Uptake of Human Papillomavirus and Other Adolescent Vaccines in the United States.
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DOI：
10.1158/1055-9965.epi-15-0574
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Brewer NT
中科院分区：
文献类型：
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作者：
Moss JL;Reiter PL;Rimer BK;Ribisl KM;Brewer NT
人乳头瘤病毒（HPV）疫苗接种的季节性可能对国家癌症预防工作产生重大影响。我们假设，美国HPV疫苗和其他青少年疫苗的接种率在夏季最高。数据来自2008-2012年国家免疫调查-青少年中70，144名青少年（13-17岁）的医疗保健提供者验证的疫苗接种记录。使用Edwards方法检测年度趋势，我们检查了HPV和其他推荐的青少年疫苗（破伤风，白喉和百日咳（Tdap）加强剂和脑膜炎球菌疫苗）的季节性摄取模式。HPV疫苗启动（接受三剂系列中的第一剂）数据针对女性青少年。HPV和其他青少年疫苗的吸收在夏季达到高峰，各年和各州（所有p<.001）。HPV疫苗高峰期的摄取频率是低谷期的5倍，HPV疫苗在6月、7月和8月开始接种的频率最高（这三个月接种的剂量百分比：38.7%）。Tdap加强疫苗和脑膜炎球菌疫苗也存在同样的模式。HPV疫苗与其他青少年疫苗的同期（同一天）接种也显示了全国每年的夏季高峰（所有p<.001）。青少年疫苗接种在夏季急剧增加。这些夏季高峰期是重点进行伴随疫苗接种的干预措施的重要机会。HPV疫苗接种计划的潜在癌症预防影响可以增加，例如，通过在夏季提供有关伴随疫苗接种的信息，此时青少年及其父母可能对他们最开放。
Seasonality in human papillomavirus (HPV) vaccination could have a large impact on national cancer prevention efforts. We hypothesized that uptake of HPV vaccine and other adolescent vaccines in the United States would be highest in the summer. Data came from healthcare provider-verified vaccination records for 70,144 adolescents (ages 13–17) from the 2008–2012 versions of the National Immunization Survey-Teen. Using the Edwards method for testing annual trends, we examined seasonal patterns in uptake of HPV and other recommended adolescent vaccines (tetanus, diphtheria, and pertussis (Tdap) booster and meningococcal vaccine). HPV vaccine initiation (receipt of the first of the three-dose series) data were for female adolescents. Uptake for HPV and other adolescent vaccines peaked in the summer across years and states (all p<.001). Uptake was 5 times as frequent at the peak as at the trough for HPV vaccine, and HPV vaccine initiation was highest in June, July, and August (percent of doses delivered in these months: 38.7%). The same pattern existed for Tdap booster and meningococcal vaccine. Concomitant (same-day) vaccination of HPV vaccine with other adolescent vaccines also demonstrated summer peaks each year nationally (all p<.001). Uptake of adolescent vaccines increased dramatically in summer months. These summer peaks are an important opportunity for interventions focused on concomitant vaccination. The potential cancer prevention impact of HPV vaccination programs could be increased, for example, by delivering messages about concomitant vaccination during the summer, when adolescents and their parents might be most open to them.