Control of flow direction in microfluidic devices with polyelectrolyte multilayers
Control of flow direction in microfluidic devices with polyelectrolyte multilayers
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DOI：
10.1021/ac0008690
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发表时间：
2000-12-15
影响因子：
7.4
通讯作者：
Locascio, LE
中科院分区：
文献类型：
--
作者：
Barker, SLR;Ross, D;Locascio, LE
电渗流（electrosomposite flow，缩写为EFT）通常用于微流体。因为微流控的方向可以由衬底表面电荷决定，所以除了电压控制之外，表面化学状态的控制提供了引导微流控装置中的流动的可能性。我们报告了使用聚苯乙烯和丙烯酸微流体装置中的纳米多层膜（PEM）来改变表面电荷和控制方向。通过用带相反电荷的聚电解质对单个器件的不同臂进行衍生化，实现了具有简单布置的施加电压的相对复杂的电流图案。此外，在同一通道中的相反方向上的流动是可能的。使用带有带负电荷的盖子的正衍生化塑料基底来实现顶部-底部相反的流动。用带相反电荷的聚电解质对塑料微通道的两侧进行衍生化，以实现并排的相反流动。流动的特点是使用荧光成像和粒子测速。
Electroosmotic flow (EOF) is commonly utilized in microfluidics. Because the direction of the EOF can be determined by the substrate surface charge, control of the surface chemical state offers the potential, in addition to voltage control, to direct the flow in microfluidic devices. We report the use of polyelectrolyte multilayers (PEMs) to alter the surface charge and control the direction of how in polystyrene and acrylic microfluidic devices. Relatively complex now patterns with simple arrangements of applied voltages are realized by derivatization of different arms of a single device with oppositely charged polyelectrolytes. In addition, flow in opposite directions in the same channel is possible. A positively derivatized plastic substrate with a negatively charged lid was used to achieve top-bottom opposite flows. Derivatization of the two sides of a plastic microchannel with oppositely charged polyelectrolytes was used to achieve side-by-side opposite flows. The flow is characterized using fluorescence imaging and particle velocimetry.