Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes
Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes
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DOI：
10.1128/aem.00681-09
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发表时间：
2009-07-15
影响因子：
4.4
通讯作者：
Ochi, Kozo
中科院分区：
文献类型：
--
作者：
Tanaka, Yukinori;Komatsu, Mamoru;Ochi, Kozo
某些链霉素抗性突变（即，rpsL和rsmG）导致各种放线菌中抗生素的过量生产。此外，rpsL rsmG双突变菌株显示出抗生素产量的进一步增加。rpsL而不是rsmG突变导致阿维链霉菌中寡霉素生产和红多孢菌中红霉素生产的显著增强，伴随着后一种生物体中关键发育调节基因bldD的转录增加。
Certain streptomycin resistance mutations (i.e., rpsL and rsmG) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a further increase in antibiotic production. rpsL but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea, accompanied by increased transcription of a key developmental regulator gene, bldD, in the latter organism.