In support of clinical case reports: a system of causality assessment.
In support of clinical case reports: a system of causality assessment.
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DOI：
10.7453/gahmj.2012.061
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发表时间：
2013-03-01
影响因子：
--
通讯作者：
Kienle, Gunver S
中科院分区：
文献类型：
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作者：
Kiene, Helmut;Hamre, Harald J;Kienle, Gunver S
临床研究的有效性取决于对因果关系的评估。这种评估决定了什么构成临床证据。病例报告是经常被忽视的证据的一个例子，因为人们认为它们不能说明治疗与结果之间的因果关系。这可能是个错误。明确因果关系及其评估的主题将有利于研究人员和临床医生。本文概述了因果关系和因果关系评估的总体体系。提出的系统包括两个维度：水平和垂直；这些维度中的每一个都由三种不同类型的因果关系和三种相应类型的因果关系评估组成。本系统包括各种形式的病例因果关系，并以日常生活和临床医学为例加以说明。在个体化医疗时代，评估病例因果关系可以补充传统的临床研究。
The usefulness of clinical research depends on an assessment of causality. This assessment determines what constitutes clinical evidence. Case reports are an example of evidence that is frequently overlooked because it is believed they cannot address causal links between treatment and outcomes. This may be a mistake. Clarity on the topic of causality and its assessment will be of benefit for researchers and clinicians. This article outlines an overall system of causality and causality assessment. The system proposed involves two dimensions: horizontal and vertical; each of these dimensions consists of three different types of causality and three corresponding types of causality assessment. Included in this system are diverse forms of case causality illustrated with examples from everyday life and clinical medicine. Assessing case causality can complement conventional clinical research in an era of personalized medicine.