Depression and obesity: evidence of shared biological mechanisms.
Depression and obesity: evidence of shared biological mechanisms.
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DOI：
10.1038/s41380-018-0017-5
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发表时间：
2019-01-01
影响因子：
11
通讯作者：
Penninx, Brenda Wjh
中科院分区：
文献类型：
--
作者：
Milaneschi, Yuri;Simmons, W Kyle;Penninx, Brenda Wjh
抑郁症和肥胖症是常见的疾病，对公共健康有重大影响，往往在个人内部同时发生。这些情况之间的关系是双向的：一种情况的存在增加了发展另一种情况的风险。因此，更好地了解与这两种情况相关的相互交织的向下生理螺旋的机制变得至关重要。目前的综述主要集中在可能从机械上解释抑郁症-肥胖症联系的共同生物途径，包括遗传学，参与体内平衡调节的系统的变化(HPA轴，免疫炎症激活，能量代谢的神经内分泌调节，包括瘦素和胰岛素，以及微生物组)，以及整合内稳态和情绪调节反应的大脑回路。此外，这篇综述还讨论了介入的机会和有待未来研究回答的问题，这些研究将使抑郁症和肥胖症之间的生物学联系能够得到全面的表征和目标。
Depression and obesity are common conditions with major public health implications that tend to co-occur within individuals. The relationship between these conditions is bidirectional: the presence of one increases the risk for developing the other. It has thus become crucial to gain a better understanding of the mechanisms responsible for the intertwined downward physiological spirals associated with both conditions. The present review focuses specifically on shared biological pathways that may mechanistically explain the depression-obesity link, including genetics, alterations in systems involved in homeostatic adjustments (HPA axis, immuno-inflammatory activation, neuroendocrine regulators of energy metabolism including leptin and insulin, and microbiome) and brain circuitries integrating homeostatic and mood regulatory responses. Furthermore, the review addresses interventional opportunities and questions to be answered by future research that will enable a comprehensive characterization and targeting of the biological links between depression and obesity.