Abdominal adiposity rather than age and sex predicts mass and regularity of GH secretion in healthy adults
Abdominal adiposity rather than age and sex predicts mass and regularity of GH secretion in healthy adults
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DOI：
10.1152/ajpendo.1997.272.6.e1108
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发表时间：
1997-06-01
影响因子：
5.1
通讯作者：
Christiansen, JS
中科院分区：
文献类型：
--
作者：
Vahl, N;Jorgensen, JOL;Christiansen, JS
我们检验了身体成分是非肥胖成年人生长激素（GH）分泌的主要预测因子这一假设。我们测量了42名健康的非肥胖成年人（22名女性和20名男性，年龄范围27-59岁，平均+/- SE体重指数= 24 +/- 0.5 kg/m2）的瘦肉和脂肪组织分布（计算机断层扫描和双能X线吸收扫描）和体能[最大耗氧量（V/dotO（2 max））]。去卷积分析用于估计24小时GH分泌和清除的具体特征。采用近似熵来量化GH释放的规律性。与年轻受试者相比，老年受试者的GH分泌估计值降低。女性有较高的估计生长激素分泌，较长的生长激素半衰期，并显示更多的不规则生长激素释放比男性。平均24小时血清GH浓度与腹内脂肪和腰臀比呈负相关，与（V）/dotO（2 max）呈正相关。多元线性回归分析显示，腹腔内脂肪是GH分泌估计值的主要决定因素。(V)在预测GH分泌方面，dotO（2 max）大于性别和年龄。我们的结论是腹部脂肪是健康非肥胖成人生长激素分泌的主要决定因素。尽管其潜在机制仍不明确，但我们的研究结果将内脏型肥胖的临床意义扩展到了向体细胞功能减退。
We tested the hypothesis that body composition is the major predictor of growth hormone (GH) secretion in nonobese adults. We measured lean and fat tissue distribution (computerized tomography and dual-energy X-ray absorptiometry scan) and physical fitness [maximal oxygen consumption ((V) over dotO(2max))] in 42 healthy nonobese adults (22 women and 20 men, age range 27-59 yr, mean +/- SE body mass index = 24 +/- 0.5 kg/m(2)). Deconvolution analysis was used to estimate specific features of 24-h GH secretion and clearance. Approximate entropy was used to quantify the regularity of GH release. Older subjects exhibited decreased estimates of GH secretion compared with younger subjects. Females had higher estimates of GH secretion, a longer GH half-life, and displayed more irregularity in GH release than males. Mean 24-h serum GH concentrations correlated inversely with intra-abdominal fat and waist-to-hip ratio and positively with (V) over dotO(2max). Multiple linear regression analysis revealed intraabdominal fat as the dominant determinant of estimates of GH secretion. (V) over dotO(2max) was more important than sex and age in predicting GH secretion. We conclude that abdominal fat is the major determinant of GH secretion in healthy nonobese adults. Although the underlying mechanisms remain elusive, our findings extend the clinical implications of visceral adiposity to include hyposomatotropism.