Left hemicranial hypoplasia in 2 patients with primary progressive aphasia
Left hemicranial hypoplasia in 2 patients with primary progressive aphasia
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DOI：
10.1001/archneur.61.2.265
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发表时间：
2004-02-01
影响因子：
--
通讯作者：
Mesulam, M
中科院分区：
文献类型：
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作者：
Alberca, R;Montes, E;Mesulam, M
背景：原发性进行性失语（PPA）导致语言功能逐渐和相对孤立的溶解。决定疾病过程选择性的因素仍然未知。我们曾推测PPA可能偶尔出现作为一种迟发性表现的遗传或获得性的弱点涉及语言网络的大脑目的：探讨PPA的易感因素结果：在2例患者中，PPA的发展与轻度左半颅发育不良的背景。与阅读障碍和儿童左颞叶损伤患者的PPA的其他观察结果一致，这2例患者支持这样的论点，即某些PPA病例可能出现在语言网络已成为阻力最小的场所的环境中。
Background: Primary progressive aphasia (PPA) leads to a gradual and relatively isolated dissolution of language function. The factors that determine the selectivity of the disease process remain unknown. We had speculated that PPA may occasionally arise as a tardive manifestation of genetic or acquired vulnerabilities involving the language network of the brain.Objective: To explore predisposing factors for PPA.Results: In 2 patients, PPA developed with a background of mild left hemicranial hypoplasia.Conclusion: In keeping with other observations of PPA in patients with dyslexia and childhood injury to the left temporal lobe, these 2 patients support the contention that some cases of PPA may arise in settings where the language network has become a locus of least resistance.