Inflammation in cardiovascular tissue engineering: the challenge to a promise: a minireview.
Inflammation in cardiovascular tissue engineering: the challenge to a promise: a minireview.
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DOI：
10.4061/2011/958247
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发表时间：
2011
影响因子：
2
通讯作者：
Simionescu DT
中科院分区：
文献类型：
--
作者：
Simionescu A;Schulte JB;Fercana G;Simionescu DT
组织工程采用支架、细胞和刺激物，以模仿靶组织或器官的功能结构。令人振奋的进展，组织工程和再生医学使我们能够设想在体外创造或在体内再生的心血管组织。这些成就有可能使医学发生革命性的变化，大大提高我们的生活水平。然而，近年来，与高度期望的愈合和重塑相比，由于植入物-宿主界面的异常反应，包括细胞增殖、纤维化、钙化和变性，热情受到阻碍。动物和临床研究强调了不受控制的慢性炎症是这些过程的主要原因。在这篇简短的综述中，我们提出了三个案例研究，强调炎症在组织工程心脏瓣膜、血管移植物和心肌中的重要性，并建议重点关注内皮屏障，这一“最后的前沿”具有调节炎症信号的天然潜力和能力。
Tissue engineering employs scaffolds, cells, and stimuli brought together in such a way as to mimic the functional architecture of the target tissue or organ. Exhilarating advances in tissue engineering and regenerative medicine allow us to envision in vitro creation or in vivo regeneration of cardiovascular tissues. Such accomplishments have the potential to revolutionize medicine and greatly improve our standard of life. However, enthusiasm has been hampered in recent years because of abnormal reactions at the implant-host interface, including cell proliferation, fibrosis, calcification and degeneration, as compared to the highly desired healing and remodeling. Animal and clinical studies have highlighted uncontrolled chronic inflammation as the main cause of these processes. In this minireview, we present three case studies highlighting the importance of inflammation in tissue engineering heart valves, vascular grafts, and myocardium and propose to focus on the endothelial barrier, the “final frontier” endowed with the natural potential and ability to regulate inflammatory signals.