Foveal cone-photoreceptor integrity in aging macula disorder
Foveal cone-photoreceptor integrity in aging macula disorder
复制标题
DOI：
10.1167/iovs.07-1181
复制
发表时间：
2008-05-01
影响因子：
4.4
通讯作者：
van Norren, Dirk
中科院分区：
文献类型：
--
作者：
Kanis, Martijn J.;Wisse, Robert P. L.;van Norren, Dirk
目的.建立AMD分期和与光学Stiles-Crawford效应相关的中央凹视锥光感受器完整性的定量测量之间的关系。最终分析包括五十六只AMD眼和57只对照眼。AMD根据国际分类系统分为五个相互排斥的阶段。0至1期标记为无AMD，2至3期标记为早期AMD，4期标记为晚期AMD。眼底反射仪，连同一个模型拟合程序，提供信息的定向锥反射（Rd），定量测量的完整性，中央凹锥光感受器。同时测量黄斑色素（MPOD）和黑色素（MOD）的光密度值。使用一般线性模型分析来比较AMD各阶段的Rd、MPOD和MOD。结果。早期AMD和晚期AMD的平均Rd分别为0.92%和0.86%，均低于非AMD期的平均Rd（1.76%，P < 0.001）。早期AMD患者的平均MPOD值（0.53，P = 0.05）无差异，但晚期AMD患者的平均MPOD值（0.19，P < 0.001）低于非AMD患者的平均MPOD值（0.42）。早期（1.09，P = 0.001）和晚期（1.01，P = 0.004）AMD的平均MOD低于非AMD阶段的平均MOD（1.23）。在早期AMD中，中心凹视锥显示出错位和/或外段恶化的迹象。黑色素而不是黄斑色素可能对AMD起保护作用，尽管这些眼部色素的丧失也可能由AMD引起。
PURPOSE. To establish the relation between AMD stage and a quantitative measure for the integrity of foveal cone photoreceptors related to the optical Stiles-Crawford effect.METHODS. Fifty-six AMD eyes and 57 control eyes were included in the final analysis. AMD was graded in accordance with the International Classification System into five mutually exclusive stages. Stages 0 to 1 were labeled no AMD, stages 2 to 3 were labeled early AMD, and stage 4 was labeled late AMD. Fundus reflectometry, together with a model-fit procedure, provided information on directional cone reflectance (Rd), a quantitative measure for the integrity of foveal cone photoreceptors. Optical densities of macular pigment (MPOD) and melanin (MOD) were also obtained. A general linear model analysis was used to compare Rd, MPOD, and MOD among the AMD stages.RESULTS. Mean Rd was lower in early AMD (0.92%, P < 0.001) and late AMD (0.86%, P < 0.001) compared with mean Rd in the no-AMD stage (1.76%). Mean MPOD was not different in early AMD (0.53, P = 0.05), but it was lower in late AMD (0.19, P < 0.001) compared with mean MPOD in the no-AMD stage (0.42). Mean MOD was lower in early (1.09, P = 0.001) and late (1.01, P = 0.004) AMD compared with mean MOD in the no-AMD stage (1.23).CONCLUSIONS. Foveal cones show signs of misalignment and/or outer segment deterioration in early AMD. Melanin rather than macular pigment may play a protective role against AMD, although loss of these ocular pigments can also be caused by AMD.