Long-term intracerebral inflammatory response after traumatic brain injury
Long-term intracerebral inflammatory response after traumatic brain injury
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DOI：
10.1016/j.forsciint.2004.06.027
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发表时间：
2004-12-16
影响因子：
2.2
通讯作者：
Nicoll, JAR
中科院分区：
文献类型：
--
作者：
Gentleman, SM;Leclercq, PD;Nicoll, JAR
流行病学和病理学研究表明，头部损伤是晚年神经退行性变和认知能力下降的重要危险因素。创伤后神经退行性变化发展的确切机制尚不清楚，但我们假设大脑中炎症过程的持续存在可能发挥关键作用，并且某些个体根据其基因构成更容易受到此类变化的影响。为了支持这一假设，我们提供了头部损伤长期幸存者中小胶质细胞活性持续升高的证据，并提出了这种活性程度与白细胞介素 1 基因型之间的关联。 (C) 2004 Elsevier Ireland Ltd. 保留所有权利。
Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype. (C) 2004 Elsevier Ireland Ltd. All rights reserved.