Long-term potentiation in the cat somatosensory cortex.
Long-term potentiation in the cat somatosensory cortex.
复制标题
猫体感皮层的长时程增强。
DOI：
10.1097/00001756-199009000-00014
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发表时间：
1990
期刊：
影响因子：
1.7
通讯作者：
Asanuma,H
中科院分区：
文献类型：
--
作者：
Keller,A;Pavlides,C;Asanuma,H
细胞内，在体内记录被用来确定在猫的体感皮层中的神经元，其中长时程增强（LTP）被诱导。在强直刺激（200 Hz，20 s）前后记录微刺激运动皮层（4区[γ]）产生的EPSP振幅。在8/13个细胞（62%）中，在强直刺激后EPSP振幅显著增加。LTP只在产生单突触EPSPs的细胞中诱导。这些细胞中的六个通过细胞内注射生物胞素来标记。LTP诱导的所有细胞都是锥体神经元，仅位于体感皮层的第II或III层;皮层深层的细胞没有增强。这些数据证实了我们以前的研究结果表明，LTP在皮质皮质通路，并建议这些途径发挥重要作用，皮质突触可塑性。
INTRACELLULAR, in-vivo recordings were used to identify neurons in the cat somatosensory cortex in which long-term potentiation (LTP) was induced. Amplitudes of EPSPs produced by microstimulation in the motor cortex (area 4 [gamma]) were recorded before and after tetanic stimulation (200Hz, 20s). In 8/13 cells (62%), EPSP amplitudes increased significantly following the tetanic stimulation. LTP was induced exclusively in cells which produced monosynaptic EPSPs. Six of these cells were labeled by intracellular injections of biocytin. All the cells in which LTP was induced were pyramidal neurons, and were located exclusively in layers II or III of the somatosensory cortex; cells in deeper cortical layers were not potentiated. These data substantiate our previous findings demonstrating LTP in corticocortical pathways and suggest that these pathways play an important role in cortical synaptic plasticity.