Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study.
Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study.
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DOI：
10.1186/1471-2261-7-20
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发表时间：
2007-07-13
影响因子：
2.1
通讯作者：
Heiss, Gerardo
中科院分区：
文献类型：
--
作者：
Bidulescu, Aurelian;Chambless, Lloyd E;Heiss, Gerardo
背景技术背景：饮食中摄入的必需营养素胆碱及其代谢物甜菜碱含量低可能会通过影响同型半胱氨酸甲基化途径以及胆碱的抗氧化剂特性而增加动脉粥样硬化的发生。许多常见食物的胆碱和甜菜碱的营养价值最近在美国营养成分数据库中可用。我们的目的是评估胆碱和甜菜碱的饮食摄入量与冠心病（CHD）事件的关联，调整饮食摄入量measurementerror.METHODS：我们进行了一项前瞻性调查，14,430名中年男性和女性的两族动脉粥样硬化风险社区研究中，胆碱和甜菜碱的日常摄入量与冠心病的风险之间的关系。半定量食物频率问卷被用来评估营养素摄入。采用比例风险回归模型计算冠心病发病风险。回归校准方法用于调整测量误差。结果：在平均14年的随访（1987-2002）中，记录了1,072例冠心病事件。与摄入量最低的四分位数相比，在控制年龄、性别、教育、总能量摄入、叶酸、蛋氨酸和维生素B6摄入量的情况下，胆碱和胆碱加甜菜碱的最高四分位数的冠心病发病风险略高，HR = 1.22（0.91，1.64）和HR = 1.14（0.85，1.53）。校正测量误差后，饮食中胆碱摄入量与冠心病发病率无相关性。结论：胆碱和甜菜碱摄入量增加对冠心病发病率无保护作用。在其他人群中进行的类似研究也很有意义。
BACKGROUND: Low dietary intake of the essential nutrient choline and its metabolite betaine may increase atherogenesis both through effects on homocysteine methylation pathways as well as through choline's antioxidants properties. Nutrient values for many common foods for choline and betaine have recently become available in the U.S. nutrient composition database. Our objective was to assess the association of dietary intake of choline and betaine with incident coronary heart disease (CHD), adjusting for dietary intake measurement error.METHODS: We conducted a prospective investigation of the relation between usual intake of choline and betaine with the risk of CHD in 14,430 middle-aged men and women of the biethnic Atherosclerosis Risk in Communities study. A semi-quantitative food frequency questionnaire was used to assess nutrient intake. Proportional hazard regression models were used to calculate the risk of incident CHD. A regression calibration method was used to adjust for measurement error.RESULTS: During an average 14 years of follow-up (1987-2002), 1,072 incident CHD events were documented. Compared with the lowest quartile of intake, incident CHD risk was slightly and non-significantly higher in the highest quartile of choline and choline plus betaine, HR = 1.22 (0.91, 1.64) and HR = 1.14 (0.85, 1.53), controlling for age, sex, education, total energy intake, dietary intakes of folate, methionine and vitamin B6. No association was found between dietary choline intake and incident CHD when correcting for measurement error.CONCLUSION: Higher intakes of choline and betaine were not protective for incident CHD. Similar investigations in other populations are of interest.