Genetic shifting: a novel approach for controlling vector-borne diseases.
Genetic shifting: a novel approach for controlling vector-borne diseases.
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DOI：
10.1016/j.pt.2014.04.005
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发表时间：
2014-06
影响因子：
9.6
通讯作者：
Tabachnick WJ
中科院分区：
文献类型：
--
作者：
Powell JR;Tabachnick WJ
使疾病媒介群体不能通过遗传方法传播病原体一直是媒介遗传学家的目标。我们概述了一种方法来实现这一目标，不涉及引入任何新的遗传变异的目标人群。相反，我们建议改变自然发生的等位基因的频率，使其具有传播的难耐性，可以将传播降低到可持续的水平以下。该计划采用了在植物和动物育种中成功使用的方法。由于没有人为构建的转基因生物（GMOs）被引入环境，该方法的争议最小。我们以埃及伊蚊和登革热病毒（DENV）为例进行说明，但指出拟议的方案一般适用于媒介传播的疾病控制。
Rendering populations of vectors of diseases incapable of transmitting pathogens through genetic methods has long been a goal of vector geneticists. We outline a method to achieve this goal that does not involve introduction of any new genetic variants to the target population. Rather we propose that shifting the frequencies of naturally occurring alleles that confer refractoriness to transmission can reduce transmission below a sustainable level. The program employs methods successfully used in plant and animal breeding. Because no artificially constructed genetically modified organisms (GMOs) are introduced into the environment, the method is minimally controversial. We use Aedes aegypti and dengue virus (DENV) for illustrative purposes, but point out the proposed program is generally applicable to vector-borne disease control.