Role of childhood growth on the risk of metabolic syndrome in obese men and women
Role of childhood growth on the risk of metabolic syndrome in obese men and women
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DOI：
10.1016/j.diabet.2008.08.008
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发表时间：
2009-04-01
影响因子：
7.2
通讯作者：
Eriksson, J. G.
中科院分区：
文献类型：
--
作者：
Salonen, M. K.;Kajantie, E.;Eriksson, J. G.
瞄准- 虽然肥胖是代谢综合征的主要特征，但并非所有肥胖个体都会发展为该综合征。我们的目的是确定早期生长的特点，保护这些人从代谢综合征。- 我们研究了2003名1934年至1944年出生于芬兰赫尔辛基的受试者。我们关注499名肥胖者（BMI >= 30 kg/m2），其中400人根据IDF 2005标准患有代谢综合征。受试者从出生到2岁有7次身高和体重测量，从2岁到11岁有8次测量。- 在肥胖的个体中，那些患有代谢综合征的人比那些没有的人有更高的平均体重指数（BMI）和更大的腰围。这两组人出生时的体型相似，但到了两岁时，那些后来患上代谢综合征的人变得更轻、更瘦，并一直保持到11岁。BMI变化预测综合征的时期是从出生到7岁。OR为0.72（95% CI：0.57-0.92）/1 S.D.。从出生到2岁，BMI增加0.63（95% CI：0.49-0.81）/1 S.D.。BMI从2岁增加到7岁。- 在肥胖个体中，与那些没有代谢综合征的人相比，那些患有代谢综合征的人从2岁到11岁更轻更瘦。这些发现支持了儿童早期生长在决定肥胖代谢后果方面的重要性。(C)2009年Elsevier Masson SAS。All rights reserved.
Aim. - Although obesity is the key characteristic of the metabolic syndrome, not all obese individuals develop the syndrome. Our aim was to identify characteristics of early growth that protect these individuals from the metabolic syndrome.Methods. - We examined 2003 subjects born in Helsinki, Finland, between 1934 and 1944. We focused on the 499 who were obese (BMI >= 30 kg/m(2)), 400 of whom had the metabolic syndrome according to IDF 2005 criteria. The subjects had a median of seven measurements of height and weight from birth to two years of age, and eight measurements from two to I I years of age.Results. - Among obese individuals, those with the metabolic syndrome had a higher mean body mass index (BMI) and larger waist circumference than those who did not. The two groups were similar in body size at birth but, by two years of age, those who later developed the metabolic syndrome were lighter and thinner, and remained so up to age I I years. The period when BMI changes were predictive of the syndrome was from birth to seven years. OR was 0.72 (95% CI: 0.57-0.92) per 1 S.D. increase in BMI from birth to two years and 0.63 (95% CI: 0.49-0.81) per 1 S.D. increase in BMI from two to seven years.Conclusion. - Among obese individuals, those who develop the metabolic syndrome were lighter and thinner from the age of two to I I years compared with those who did not. These findings support the importance of early childhood growth in determining the metabolic consequences of obesity. (C) 2009 Elsevier Masson SAS. All rights reserved.